Literature DB >> 9617766

Interactions between cellular actin and human respiratory syncytial virus (HRSV).

L Ulloa1, R Serra, A Asenjo, N Villanueva.   

Abstract

Actin the main component of the cellular microfilament network, is present in human respiratory syncytial virus (HRSV) purified virions, as an internal component. This fact and the results of immunoprecipitation studies indicate that during HRSV infection in HEp-2 cells there are interactions between cellular actin and viral components, that can promote a transitory increase in the polymerization of synthetized actin, mainly of the beta isotype. This increased actin polymerization can be related with the formation of cytoplasmic extensions, that contain beta actin and viral particles observed in the HRSV infected HEp-2 cells. The formation of these structures may indicate that HRSV has developed an actin-based motility system similar to that described for other viral and bacterial systems.

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Year:  1998        PMID： 9617766     DOI： 10.1016/s0168-1702(97)00121-4

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  32 in total

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9.  Respiratory Syncytial Virus and Human Metapneumovirus Infections in Three-Dimensional Human Airway Tissues Expose an Interesting Dichotomy in Viral Replication, Spread, and Inhibition by Neutralizing Antibodies.

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10.  Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2.

Authors:  Thomas J Utley; Nicole A Ducharme; Vasundhara Varthakavi; Bryan E Shepherd; Philip J Santangelo; Michael E Lindquist; James R Goldenring; James E Crowe
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-09       Impact factor: 11.205
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