Literature DB >> 9616126

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.

M Tamura1, J Gu, K Matsumoto, S Aota, R Parsons, K M Yamada.   

Abstract

The tumor suppressor PTEN is a phosphatase with sequence similarity to the cytoskeletal protein tensin. Here the cellular roles of PTEN were investigated. Overexpression of PTEN inhibited cell migration, whereas antisense PTEN enhanced migration. Integrin-mediated cell spreading and the formation of focal adhesions were down-regulated by wild-type PTEN but not by PTEN with an inactive phosphatase domain. PTEN interacted with the focal adhesion kinase FAK and reduced its tyrosine phosphorylation. Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix.

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Year:  1998        PMID： 9616126     DOI： 10.1126/science.280.5369.1614

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  353 in total

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