Literature DB >> 9616121

The tetrameric structure of a glutamate receptor channel.

C Rosenmund1, Y Stern-Bach, C F Stevens.   

Abstract

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

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Year:  1998        PMID： 9616121     DOI： 10.1126/science.280.5369.1596

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  267 in total

Review 1.  Selective targeting of glutamate receptors in neurons.

Authors:  M E Rubio
Journal:  Mol Neurobiol       Date:  2000 Feb-Apr       Impact factor: 5.590

Review 2.  General anaesthetic actions on ligand-gated ion channels.

Authors:  M D Krasowski; N L Harrison
Journal:  Cell Mol Life Sci       Date:  1999-08-15       Impact factor: 9.261

3.  Differential distribution of intracellular glutamate receptors in dendrites.

Authors:  M E Rubio; R J Wenthold
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

4.  Heterogeneous conductance levels of native AMPA receptors.

Authors:  T C Smith; L Y Wang; J R Howe
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

5.  Evaluation of the number of agonist molecules needed to activate a ligand-gated channel from the current rising phase.

Authors:  E Ratner; O Tour; H Parnas
Journal:  Biophys J       Date:  2000-02       Impact factor: 4.033

6.  Domain interactions regulating ampa receptor desensitization.

Authors:  K M Partin
Journal:  J Neurosci       Date:  2001-03-15       Impact factor: 6.167

7.  Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes.

Authors:  S G Brickley; S G Cull-Candy; M Farrant
Journal:  J Neurosci       Date:  1999-04-15       Impact factor: 6.167

Review 8.  Regulation of ion channel expression in neural cells by hormones and growth factors.

Authors:  L J Chew; V Gallo
Journal:  Mol Neurobiol       Date:  1998-12       Impact factor: 5.590

9.  Subunit interactions and AMPA receptor desensitization.

Authors:  A Robert; S N Irizarry; T E Hughes; J R Howe
Journal:  J Neurosci       Date:  2001-08-01       Impact factor: 6.167

10.  Mathematical modelling of non-stationary fluctuation analysis for studying channel properties of synaptic AMPA receptors.

Authors:  T A Benke; A Lüthi; M J Palmer; M A Wikström; W W Anderson; J T Isaac; G L Collingridge
Journal:  J Physiol       Date:  2001-12-01       Impact factor: 5.182
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