BACKGROUND: Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. RESULTS: During the oral glucose tolerance test (OGTT), plasma concentration of protein-bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non-insulin-dependent diabetes mellitus (NIDDM) subjects. Total plasma radical-trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co-operation, was also significantly reduced. CONCLUSION: This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.
BACKGROUND:Free radical production has been reported to be increased in patients with diabetes mellitus, and it has been suggested that hyperglycaemia may directly contribute to the generation of oxidative stress. The aim of the present study was to evaluate the effects of an acute increase in glycaemia on plasma antioxidant defences. RESULTS: During the oral glucose tolerance test (OGTT), plasma concentration of protein-bound sulphydryl (SH) groups, vitamin C, vitamin E and uric acid significantly decreased in normal as well as non-insulin-dependent diabetes mellitus (NIDDM) subjects. Total plasma radical-trapping activity, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual co-operation, was also significantly reduced. CONCLUSION: This finding supports the hypothesis that hyperglycaemia may, even acutely, induce an oxidative stress.
Authors: Marie E Thoma; Mark A Klebanoff; Alisha J Rovner; Tonja R Nansel; Yasmin Neggers; William W Andrews; Jane R Schwebke Journal: J Nutr Date: 2011-07-06 Impact factor: 4.798
Authors: Filiz Aydoğan; Eren Taştan; Emine Aydın; Mehmet Senes; Sükran Akgedik; Rukiye Berkem; Ahmet Tekeli; Aylin Haklıgör; Hüseyin Ustün Journal: Indian J Otolaryngol Head Neck Surg Date: 2012-01-06
Authors: Miriam Jacome-Sosa; Elizabeth J Parks; Richard S Bruno; Esra Tasali; Gary F Lewis; Barbara O Schneeman; Tia M Rains Journal: Adv Nutr Date: 2016-03-15 Impact factor: 8.701