Literature DB >> 961547

Inactivation of bradykinin the plumonary circulation.

J M Stewart.   

Abstract

Bradykinin is very efficiently inactivated on passage through the pulmonary circulation by enzymes on the vascular walls. Several different cleavages of the bradykinin molecule have been observed; one appears to be due to angiotensin converting enzyme. Several types of inhibitors have been useful in the study of these pulmonary peptidases and have helped increase understanding of the functioning of the angiotensin and plasma kinin systems.

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Year:  1976        PMID： 961547     DOI： 10.1007/BF01973267

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

Review 1.  Biological and biochemical properties of angiotensin-converting enzyme.

Authors:  R L Soffer; M Das; P R Caldwell; B C Seegal; K C Hsu
Journal:  Agents Actions       Date:  1976-07

2.  Hydrolysis of bradykinin by angiotensin-converting enzyme.

Authors:  F E Dorer; J R Kahn; K E Lentz; M Levine; L T Skeggs
Journal:  Circ Res       Date:  1974-06       Impact factor: 17.367

3.  Alkylating analogs of peptide hormones. 1. Synthesis and properties of p-(N,N-)-bis(2-chloroethyl)amino)phenylbutyryl derivatives of bradykinin and bradykinin potentiating factor.

Authors:  R J Freer; J M Stewart
Journal:  J Med Chem       Date:  1972-01       Impact factor: 7.446

4.  Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis.

Authors:  M A Ondetti; N J Williams; E F Sabo; J Pluscec; E R Weaver; O Kocy
Journal:  Biochemistry       Date:  1971-10-26       Impact factor: 3.162

5.  Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme.

Authors:  F Dorer; J W Ryan; J M Stewart
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

6.  Non-identity between pulmonary bradykininase and converting-enzyme activity.

Authors:  H W Scholz; P Biron
Journal:  Rev Can Biol       Date:  1969-09

7.  Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom.

Authors:  S H Ferreira; D C Bartelt; L J Greene
Journal:  Biochemistry       Date:  1970-06-23       Impact factor: 3.162

Review 8.  The release and fate of vaso-active hormones in the circulation.

Authors:  J R Vane
Journal:  Br J Pharmacol       Date:  1969-02       Impact factor: 8.739

9.  Assay of kinins by their effects on blood pressure.

Authors:  J Roblero; J W Ryan; J M Stewart
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1973-07

10.  In vivo pulmonary metabolism of bradykinin, angiotensin I and 5-hydroxtryptamine in the rat.

Authors:  R J Freer; J M Stewart
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-09
  10 in total

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