BACKGROUND: The biological behavior of signet-ring cell carcinomas in colorectum tends to be worse than that of mucinous carcinomas. However, in previous studies, clinicopathological features of this disease have been somewhat ill-defined because various histological criteria of this disease were adopted. METHODS: We selected 11 cases of signet-ring cell carcinomas and 29 cases of mucinous carcinomas among 1595 consecutive colorectal carcinomas on defined criteria and compared clinicopathological and molecular biological features between these two types of carcinomas. RESULTS: Clinical staging of signet-ring cell carcinomas were far advanced and their prognosis tended to be worse than that of mucinous carcinomas. Furthermore, the incidence of K-ras mutations in signet-ring cell and mucinous carcinomas showed no difference between these two types of carcinomas. However, the incidence of K-ras mutation in these diseases was slightly lower than that in 30 ordinary colorectal carcinomas examined as a comparison. CONCLUSIONS: These results suggest that the carcinogenesis of signet-ring cell and mucinous carcinomas are different from that of ordinary colorectal carcinomas and that there may exist other genes related to malignancy of signet-ring cell carcinomas.
BACKGROUND: The biological behavior of signet-ring cell carcinomas in colorectum tends to be worse than that of mucinous carcinomas. However, in previous studies, clinicopathological features of this disease have been somewhat ill-defined because various histological criteria of this disease were adopted. METHODS: We selected 11 cases of signet-ring cell carcinomas and 29 cases of mucinous carcinomas among 1595 consecutive colorectal carcinomas on defined criteria and compared clinicopathological and molecular biological features between these two types of carcinomas. RESULTS: Clinical staging of signet-ring cell carcinomas were far advanced and their prognosis tended to be worse than that of mucinous carcinomas. Furthermore, the incidence of K-ras mutations in signet-ring cell and mucinous carcinomas showed no difference between these two types of carcinomas. However, the incidence of K-ras mutation in these diseases was slightly lower than that in 30 ordinary colorectal carcinomas examined as a comparison. CONCLUSIONS: These results suggest that the carcinogenesis of signet-ring cell and mucinous carcinomas are different from that of ordinary colorectal carcinomas and that there may exist other genes related to malignancy of signet-ring cell carcinomas.
Authors: Simone Sibio; A Di Giorgio; S D'Ugo; G Palmieri; L Cinelli; V Formica; B Sensi; G Bagaglini; S Di Carlo; V Bellato; G S Sica Journal: Langenbecks Arch Surg Date: 2019-11-23 Impact factor: 3.445
Authors: Leonardo Saúl Lino-Silva; Rosa A Salcedo-Hernández; Erika B Ruiz-García; Alberto M León-Takahashi; Leticia García-Pérez Journal: J Gastrointest Oncol Date: 2017-02
Authors: Mariana Troncoso; F Darío Cuello Carrión; Elina Guiñazu; Mariel A Fanelli; Magdalena Montt-Guevara; Rómulo L Cabrini; Rubén W Carón; Erica L Kreimann Journal: Horm Cancer Date: 2011-08 Impact factor: 3.869
Authors: Alia M Attia; Ashraf Farrag; Noha M Attia; Lamiaa Mr Khalaf; Hesham M Hassan; Mahmoud Gamal Ameen; Ebrahim Aboeleuon; Sanaa Saber Abd El-Raheem; Ahmed Mahran; Ahmed Mubarak Hefni Journal: Am J Cancer Res Date: 2022-03-15 Impact factor: 6.166