Literature DB >> 9612814

Surgical management of circumscribed conjunctival melanomas.

J A Shields1, C L Shields, P De Potter.   

Abstract

Circumscribed conjunctival melanoma usually arises in the bulbar conjunctiva and less often in the forniceal or palpebral conjunctiva. After simple superficial removal, employed by many ophthalmologists, these tumors have an increased tendency toward local recurrence and distant metastasis. A surgical procedure designed to remove the tumors completely and minimize the changes of recurrence would be desirable. The authors employed a surgical approach to conjunctival melanoma excision, which they believe insures more complete tumor removal and decreases the chances of recurrence and metastasis. The surgical management of melanoma in the limbal region of the bulbar conjunctiva consists of localized alcohol epitheliectomy, removal of the mass by a partial lamellar scleroconjunctivectomy, and supplemental double freeze-thaw cryotherapy to the adjacent remaining conjunctiva by a specific technique. For tumors located in the forniceal or palpebral conjunctiva, wide surgical resection with alcohol treatment to the scleral base and cryotherapy to the surrounding conjunctiva is performed. A "no touch" technique is employed and direct manipulation of the tumor is strictly avoided in an effort to prevent tumor cell seeding into a new area. The technique currently employed has evolved from experience with circumscribed conjunctival melanoma excision during a 20-year period. About 80 patients had circumscribed conjunctival melanoma unassociated with appreciable primary acquired melanosis. Although it is not the purpose of this article on surgical technique to provided a detailed statistical analysis of the results, the authors currently believe that this technique should be employed in all cases of circumscribed lesions in which conjunctival melanoma is a diagnostic consideration. Incisional biopsy and frozen sections are generally not advisable. Preliminary observations suggest that this method decreases the chances of local recurrence.

Entities:  

Mesh:

Year:  1998        PMID: 9612814     DOI: 10.1097/00002341-199805000-00012

Source DB:  PubMed          Journal:  Ophthalmic Plast Reconstr Surg        ISSN: 0740-9303            Impact factor:   1.746


  17 in total

1.  Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection.

Authors:  Iku Kikuchi; Satoru Kase; Kan Ishijima; Susumu Ishida
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2017-07-27       Impact factor: 3.117

Review 2.  Advances in the management of conjunctival melanoma.

Authors:  Gargi K Vora; Hakan Demirci; Brian Marr; Prithvi Mruthyunjaya
Journal:  Surv Ophthalmol       Date:  2016-06-16       Impact factor: 6.048

3.  Amniotic membrane transplantation for reconstruction after excision of large ocular surface neoplasias.

Authors:  E M Espana; P Prabhasawat; M Grueterich; A Solomon; S C G Tseng
Journal:  Br J Ophthalmol       Date:  2002-06       Impact factor: 4.638

4.  Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma.

Authors:  Nadine E de Waard; Paraskevi E Kolovou; Sean P McGuire; Jinfeng Cao; Natasha Y Frank; Markus H Frank; Martine J Jager; Bruce R Ksander
Journal:  Ocul Oncol Pathol       Date:  2015-04

5.  Prognostic value of clinical and histopathological parameters in conjunctival melanomas: a retrospective study.

Authors:  Gerasimos Anastassiou; Arnd Heiligenhaus; Nikos Bechrakis; Elisabeth Bader; Norbert Bornfeld; Klaus-Peter Steuhl
Journal:  Br J Ophthalmol       Date:  2002-02       Impact factor: 4.638

6.  Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience.

Authors:  Madhavi Kurli; Paul T Finger
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2005-06-07       Impact factor: 3.117

7.  Excision with corneoscleral lamellar keratoplasty and amniotic membrane transplantation of a corneal displaced recurrent conjunctival melanoma.

Authors:  Eun Chul Kim; Man Soo Kim; Nam Yeo Kang
Journal:  Korean J Ophthalmol       Date:  2012-09-24

Review 8.  Mitomycin: clinical applications in ophthalmic practice.

Authors:  Lekha M Abraham; Dinesh Selva; Robert Casson; Igal Leibovitch
Journal:  Drugs       Date:  2006       Impact factor: 9.546

Review 9.  [Adjuvant therapy and interdisciplinary follow-up care of conjunctival melanoma].

Authors:  L M Heindl; K R Koch; M Schlaak; C Mauch; C Cursiefen
Journal:  Ophthalmologe       Date:  2015-11       Impact factor: 1.059

10.  Conjunctival melanoma: a review of conceptual and treatment advances.

Authors:  Li-Anne Lim; Michele C Madigan; R Max Conway
Journal:  Clin Ophthalmol       Date:  2013-03-13
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