Literature DB >> 9611767

Prebiotic chemistry of phosphonic acids: products derived from phosphonoacetaldehyde in the presence of formaldehyde.

R M De Graaf1, J Visscher, A W Schwartz.   

Abstract

Phosphonoacetaldehyde (PAL), a phosphonic acid analogue of glycolaldehyde phosphate, reacts in the presence of formaldehyde under mildly basic conditions to produce several new products. The reaction proceeds in two stages: a fast aldol condensation of formaldehyde with PAL, and a slower reaction to produce products containing two phosphonic acid groups. We report on the derivatization, isolation by means of HPLC and characterization of these compounds. One of the products is of potential interest as a building block for a prebiotic informational polymer.

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Year:  1998        PMID： 9611767     DOI： 10.1023/a:1006543225618

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN： 0169-6149            Impact factor:   1.950


  7 in total

1.  The mechanism of synthesis of amino acids by electric discharges.

Authors:  S L MILLER
Journal:  Biochim Biophys Acta       Date:  1957-03

2.  Speculation on the RNA precursor problem.

Authors:  A W Schwartz
Journal:  J Theor Biol       Date:  1997-08-21       Impact factor: 2.691

3.  Reactive Phosphonic Acids as Prebiotic Carriers of Phosphorus

Authors: 
Journal:  J Mol Evol       Date:  1997-03       Impact factor: 2.395

4.  Prebiotic phosphorus chemistry reconsidered.

Authors:  A W Schwartz
Journal:  Orig Life Evol Biosph       Date:  1997-12       Impact factor: 1.950

5.  Alkyl phosphonic acids and sulfonic acids in the Murchison meteorite.

Authors:  G W Cooper; W M Onwo; J R Cronin
Journal:  Geochim Cosmochim Acta       Date:  1992       Impact factor: 5.010

6.  A plausibly prebiotic synthesis of phosphonic acids.

Authors:  R M de Graaf; J Visscher; A W Schwartz
Journal:  Nature       Date:  1995-11-30       Impact factor: 49.962

7.  Determination of monosaccharides in glycoproteins by reverse-phase high-performance liquid chromatography.

Authors:  H Kwon; J Kim
Journal:  Anal Biochem       Date:  1993-12       Impact factor: 3.365
  7 in total
  4 in total

1.  Phosphorus: a case for mineral-organic reactions in prebiotic chemistry.

Authors:  Matthew Pasek; Barry Herschy; Terence P Kee
Journal:  Orig Life Evol Biosph       Date:  2015-03-14       Impact factor: 1.950

2.  Rethinking early Earth phosphorus geochemistry.

Authors:  Matthew A Pasek
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-14       Impact factor: 11.205

3.  Concept of sustained ordering and an ATP-related mechanism of life's origin.

Authors:  Erik M Galimov
Journal:  Int J Mol Sci       Date:  2009-05-06       Impact factor: 6.208

4.  Systematic identification and analysis of frequent gene fusion events in metabolic pathways.

Authors:  Christopher S Henry; Claudia Lerma-Ortiz; Svetlana Y Gerdes; Jeffrey D Mullen; Ric Colasanti; Aleksey Zhukov; Océane Frelin; Jennifer J Thiaville; Rémi Zallot; Thomas D Niehaus; Ghulam Hasnain; Neal Conrad; Andrew D Hanson; Valérie de Crécy-Lagard
Journal:  BMC Genomics       Date:  2016-06-24       Impact factor: 3.969
  4 in total

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