C M Adler1, T E Goldberg, A K Malhotra, D Pickar, A Breier. 1. Experimental Therapeutics Branch, National Institute of Mental Health, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Abstract
BACKGROUND: The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS: We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with ketamine. Ten healthy volunteers underwent a double-blind, placebo-controlled, ketamine infusion (0.12 mg/kg bolus and 0.65 mg/kg/hour). Thought disorder was evaluated with the Scale for the Assessment of Thought, Language and Communication. Cognitive testing involved working and semantic memory tasks. RESULTS:Ketamine produced a formal thought disorder, as well as impairments in working and semantic memory. The degree of ketamine-induced thought disorder significantly correlated with ketamine-induced decreases in working memory and did not correlate with ketamine-induced impairments in semantic memory. CONCLUSIONS: This study characterizes the formal thought disorder associated with ketamine and may suggest that ketamine-induced deficits in working memory are associated with ketamine-induced thought disorder.
RCT Entities:
BACKGROUND: The N-methyl-D-aspartate receptor antagonist, ketamine, produces a clinical syndrome of thought disorder, perceptual distortion, and cognitive impairment. METHODS: We have administered ketamine to healthy volunteers to characterize the formal thought disorder and specific memory dysfunction associated with ketamine. Ten healthy volunteers underwent a double-blind, placebo-controlled, ketamine infusion (0.12 mg/kg bolus and 0.65 mg/kg/hour). Thought disorder was evaluated with the Scale for the Assessment of Thought, Language and Communication. Cognitive testing involved working and semantic memory tasks. RESULTS:Ketamine produced a formal thought disorder, as well as impairments in working and semantic memory. The degree of ketamine-induced thought disorder significantly correlated with ketamine-induced decreases in working memory and did not correlate with ketamine-induced impairments in semantic memory. CONCLUSIONS: This study characterizes the formal thought disorder associated with ketamine and may suggest that ketamine-induced deficits in working memory are associated with ketamine-induced thought disorder.
Authors: Anita K Roopun; Mark O Cunningham; Claudia Racca; Kai Alter; Roger D Traub; Miles A Whittington Journal: Schizophr Bull Date: 2008-06-09 Impact factor: 9.306
Authors: C M Corcoran; J G Keilp; J Kayser; C Klim; P D Butler; G E Bruder; R C Gur; D C Javitt Journal: Psychol Med Date: 2015-06-04 Impact factor: 7.723
Authors: Adriana M Marques; Michele V Macena; Aline R Cardoso; Camila S O Hammes; Fernanda M L Pinheiro; Newton G Castro; Gilda A Neves Journal: Psychopharmacology (Berl) Date: 2020-02-24 Impact factor: 4.530
Authors: Jeffrey R Bishop; James L Reilly; Margret S H Harris; Shitalben R Patel; Rick Kittles; Judith A Badner; Konasale M Prasad; Vishwajit L Nimgaonkar; Matcheri S Keshavan; John A Sweeney Journal: Psychopharmacology (Berl) Date: 2014-08-07 Impact factor: 4.530
Authors: Tahir Hakami; Nigel C Jones; Elena A Tolmacheva; Julien Gaudias; Joseph Chaumont; Michael Salzberg; Terence J O'Brien; Didier Pinault Journal: PLoS One Date: 2009-08-25 Impact factor: 3.240