Literature DB >> 9610806

The North Cumbria Community Genetics Project.

D S Chase1, E J Tawn, L Parker, P Jonas, C O Parker, J Burn.   

Abstract

The aim of the North Cumbria Community Genetics Project is to establish a store of DNA, plasma, and viable cells from a cohort of around 8000 Cumbrian infants. To meet this objective, specimens of umbilical cord blood and tissue will be collected with maternal consent from babies born at the West Cumberland Hospital, Whitehaven over a five year period from January 1996. These samples will be used in a series of genetic and epidemiological studies investigating the interaction between genes, the environment, and health. There is little population movement in West Cumbria and so it will be possible to follow many of the babies throughout their childhood and to investigate the relationship between their genetic constitution and health outcome.

Entities:  

Mesh：

Year:  1998        PMID： 9610806      PMCID： PMC1051317          DOI： 10.1136/jmg.35.5.413

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  8 in total

1.  Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria.

Authors:  M J Gardner; M P Snee; A J Hall; C A Powell; S Downes; J D Terrell
Journal:  BMJ       Date:  1990-02-17

2.  Ethical issues in international collaborative research on the human genome: the HGP and the HGDP.

Authors:  B M Knoppers; M Hirtle; S Lormeau
Journal:  Genomics       Date:  1996-06-01       Impact factor: 5.736

Review 3.  Genetics: changing health care in the 21st century.

Authors:  S L Jones
Journal:  J Obstet Gynecol Neonatal Nurs       Date:  1996 Nov-Dec

4.  The repeatability of self-reported exposure after miscarriage. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.

Authors:  A Farrow; S C Farrow; R Little; J Golding
Journal:  Int J Epidemiol       Date:  1996-08       Impact factor: 7.196

5.  Study of the aetiology of wheezing illness at age 16 in two national British birth cohorts.

Authors:  S Lewis; B Butland; D Strachan; J Bynner; D Richards; N Butler; J Britton
Journal:  Thorax       Date:  1996-07       Impact factor: 9.139

Review 6.  Paternal exposure not to blame.

Authors:  R Doll; H J Evans; S C Darby
Journal:  Nature       Date:  1994-02-24       Impact factor: 49.962

7.  Geographical distribution of preconceptional radiation doses to fathers employed at the Sellafield nuclear installation, West Cumbria.

Authors:  L Parker; A W Craft; J Smith; H Dickinson; R Wakeford; K Binks; D McElvenny; L Scott; A Slovak
Journal:  BMJ       Date:  1993-10-16

8.  Mutation analysis for cystic fibrosis to determine carrier status in 167 sperm donors from the Nebraska Genetic Semen Bank.

Authors:  M D Traystman; N A Schulte; M MacDonald; J R Anderson; W G Sanger
Journal:  Hum Mutat       Date:  1994       Impact factor: 4.878
  8 in total
  12 in total

1.  Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.

Authors:  C L Relton; C S Wilding; M S Pearce; A J Laffling; P A Jonas; S A Lynch; E J Tawn; J Burn
Journal:  J Med Genet       Date:  2004-04       Impact factor: 6.318

2.  Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.

Authors:  Mieke Schutte; Sheila Seal; Rita Barfoot; Hanne Meijers-Heijboer; Marijke Wasielewski; D Gareth Evans; Diana Eccles; Carel Meijers; Frans Lohman; Jan Klijn; Ans van den Ouweland; P Andrew Futreal; Katherine L Nathanson; Barbara L Weber; Douglas F Easton; Michael R Stratton; Nazneen Rahman
Journal:  Am J Hum Genet       Date:  2003-02-27       Impact factor: 11.025

3.  Genetic selection? A study of individual variation in the enzymes of folate metabolism.

Authors:  Barbara A Jennings; Gavin A Willis; Jane Skinner; Caroline L Relton
Journal:  BMC Med Genet       Date:  2010-02-01       Impact factor: 2.103

4.  Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.

Authors:  Sara J Brown; Caroline L Relton; Haihui Liao; Yiwei Zhao; Aileen Sandilands; Ian J Wilson; John Burn; Nick J Reynolds; W H Irwin McLean; Heather J Cordell
Journal:  J Allergy Clin Immunol       Date:  2008-03-04       Impact factor: 10.793

5.  A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot.

Authors:  Judith A Goodship; Darroch Hall; Ana Topf; Chrysovalanto Mamasoula; Helen Griffin; Thahira J Rahman; Elise Glen; Huay Tan; Julian Palomino Doza; Caroline L Relton; Jamie Bentham; Shoumo Bhattacharya; Catherine Cosgrove; David Brook; Javier Granados-Riveron; Frances A Bu'Lock; John O'Sullivan; A Graham Stuart; Jonathan Parsons; Heather J Cordell; Bernard Keavney
Journal:  Circ Cardiovasc Genet       Date:  2012-04-13

6.  Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

Authors:  Rachel M Freathy; Michael N Weedon; Amanda Bennett; Elina Hypponen; Caroline L Relton; Beatrice Knight; Beverley Shields; Kirstie S Parnell; Christopher J Groves; Susan M Ring; Marcus E Pembrey; Yoav Ben-Shlomo; David P Strachan; Chris Power; Marjo-Riitta Jarvelin; Mark I McCarthy; George Davey Smith; Andrew T Hattersley; Timothy M Frayling
Journal:  Am J Hum Genet       Date:  2007-04-23       Impact factor: 11.025

7.  Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12.

Authors:  Jill A McKay; Alexandra Groom; Catherine Potter; Lisa J Coneyworth; Dianne Ford; John C Mathers; Caroline L Relton
Journal:  PLoS One       Date:  2012-03-30       Impact factor: 3.240

8.  Pathogenic mitochondrial DNA mutations are common in the general population.

Authors:  Hannah R Elliott; David C Samuels; James A Eden; Caroline L Relton; Patrick F Chinnery
Journal:  Am J Hum Genet       Date:  2008-08       Impact factor: 11.025

9.  Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight.

Authors:  Jessica Tyrrell; Ville Huikari; Jennifer T Christie; Alana Cavadino; Rachel Bakker; Marie-Jo A Brion; Frank Geller; Lavinia Paternoster; Ronny Myhre; Catherine Potter; Paul C D Johnson; Shah Ebrahim; Bjarke Feenstra; Anna-Liisa Hartikainen; Andrew T Hattersley; Albert Hofman; Marika Kaakinen; Lynn P Lowe; Per Magnus; Alex McConnachie; Mads Melbye; Jane W Y Ng; Ellen A Nohr; Chris Power; Susan M Ring; Sylvain P Sebert; Verena Sengpiel; H Rob Taal; Graham C M Watt; Naveed Sattar; Caroline L Relton; Bo Jacobsson; Timothy M Frayling; Thorkild I A Sørensen; Jeffrey C Murray; Debbie A Lawlor; Craig E Pennell; Vincent W V Jaddoe; Elina Hypponen; William L Lowe; Marjo-Riitta Jarvelin; George Davey Smith; Rachel M Freathy
Journal:  Hum Mol Genet       Date:  2012-09-05       Impact factor: 6.150

10.  Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot.

Authors:  Julian Palomino Doza; Ana Topf; Jamie Bentham; Shoumo Bhattacharya; Catherine Cosgrove; J David Brook; Javier Granados-Riveron; Frances A Bu'Lock; John O'Sullivan; A Graham Stuart; Jonathan Parsons; Caroline Relton; Judith Goodship; Deborah J Henderson; Bernard Keavney
Journal:  BMC Genet       Date:  2013-06-19       Impact factor: 2.797
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