Literature DB >> 9610679

Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease.

G A Cabral1, D A Dove Pettit.   

Abstract

Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans.

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Year:  1998        PMID： 9610679     DOI： 10.1016/s0165-5728(97)00227-0

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  38 in total

Review 1.  Microbial infections, immunomodulation, and drugs of abuse.

Authors:  Herman Friedman; Catherine Newton; Thomas W Klein
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

2.  Perinatal exposure to Δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens.

Authors:  Catherine Lombard; Venkatesh L Hegde; Mitzi Nagarkatti; Prakash S Nagarkatti
Journal:  J Pharmacol Exp Ther       Date:  2011-08-10       Impact factor: 4.030

3.  Exposure of Adolescent Mice to Delta-9-Tetrahydrocannabinol Induces Long-Lasting Modulation of Pro- and Anti-Inflammatory Cytokines in Hypothalamus and Hippocampus Similar to that Observed for Peripheral Macrophages.

Authors:  Sarah Moretti; Silvia Franchi; Mara Castelli; Giada Amodeo; Lorenzo Somaini; Alberto Panerai; Paola Sacerdote
Journal:  J Neuroimmune Pharmacol       Date:  2015-02-10       Impact factor: 4.147

Review 4.  Drugs of abuse, immune modulation, and AIDS.

Authors:  Guy A Cabral
Journal:  J Neuroimmune Pharmacol       Date:  2006-06-28       Impact factor: 4.147

Review 5.  Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation.

Authors:  Guy A Cabral; LaToya Griffin-Thomas
Journal:  Expert Rev Mol Med       Date:  2009-01-20       Impact factor: 5.600

Review 6.  Targeting the endocannabinoid system in Alzheimer's disease.

Authors:  Jeremy Koppel; Peter Davies
Journal:  J Alzheimers Dis       Date:  2008-11       Impact factor: 4.472

Review 7.  HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse.

Authors:  Kurt F Hauser; Nazira El-Hage; Anne Stiene-Martin; William F Maragos; Avindra Nath; Yuri Persidsky; David J Volsky; Pamela E Knapp
Journal:  J Neurochem       Date:  2006-12-01       Impact factor: 5.372

8.  Cannabis and endocannabinoid modulators: Therapeutic promises and challenges.

Authors:  Igor Grant; B Rael Cahn
Journal:  Clin Neurosci Res       Date:  2005

9.  CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

Authors:  Jeremy Koppel; Valerie Vingtdeux; Philippe Marambaud; Cristina d'Abramo; Heidy Jimenez; Mark Stauber; Rachel Friedman; Peter Davies
Journal:  Mol Med       Date:  2013-11-08       Impact factor: 6.354

10.  Association of marijuana smoking with oropharyngeal and oral tongue cancers: pooled analysis from the INHANCE consortium.

Authors:  Morgan A Marks; Anil K Chaturvedi; Karl Kelsey; Kurt Straif; Julien Berthiller; Stephen M Schwartz; Elaine Smith; Annah Wyss; Paul Brennan; Andrew F Olshan; Qingyi Wei; Erich M Sturgis; Zuo-Feng Zhang; Hal Morgenstern; Joshua Muscat; Philip Lazarus; Michael McClean; Chu Chen; Thomas L Vaughan; Victor Wunsch-Filho; Maria Paula Curado; Sergio Koifman; Elena Matos; Ana Menezes; Alexander W Daudt; Leticia Fernandez; Marshall Posner; Paolo Boffetta; Yuan-Chin Amy Lee; Mia Hashibe; Gypsyamber D'Souza
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2013-12-18       Impact factor: 4.254
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