PURPOSE: Following parenteral magnesium tocolysis for patients in preterm labor. The choice of oral tocolytic medications is controversial. METHODS: Over a six-month period, 47 patients who were inpreterm labor were randomized after parenteral magnesium tocolysis to receive magnesium gluconate ([Mg-g] 648 mg elemental magnesium/day) or magnesium chloride ([Mg-c] 640 mg elemental magnesium/ day). A serum magnesium was obtained 24 hours after the initiation of oral therapy. RESULTS: In the 25 patients were treated with Mg-g and 22 with Mg-c there were no differences in patient demographics, initial cervical dilatation hours on parenteral magnesium sulfate, recurrent contractions, or side effects between the two groups. The cost was also similar (Mg-c, $1.40/d; Mg-g, $2.11/d). The serum magnesium levels were higher in the Mg-c group (1.80 +/- 0.28 mg/dl) compared to the Mg-g group (1.63 +/- 0.30 mg/dl) but the difference was not significant. CONCLUSION: These two preparations of magnesium are similar in their effects on uterine activity and serum levels when used at these dosages.
RCT Entities:
PURPOSE: Following parenteral magnesium tocolysis for patients in preterm labor. The choice of oral tocolytic medications is controversial. METHODS: Over a six-month period, 47 patients who were inpreterm labor were randomized after parenteral magnesium tocolysis to receive magnesium gluconate ([Mg-g] 648 mg elemental magnesium/day) or magnesium chloride ([Mg-c] 640 mg elemental magnesium/ day). A serum magnesium was obtained 24 hours after the initiation of oral therapy. RESULTS: In the 25 patients were treated with Mg-g and 22 with Mg-c there were no differences in patient demographics, initial cervical dilatation hours on parenteral magnesium sulfate, recurrent contractions, or side effects between the two groups. The cost was also similar (Mg-c, $1.40/d; Mg-g, $2.11/d). The serum magnesium levels were higher in the Mg-c group (1.80 +/- 0.28 mg/dl) compared to the Mg-g group (1.63 +/- 0.30 mg/dl) but the difference was not significant. CONCLUSION: These two preparations of magnesium are similar in their effects on uterine activity and serum levels when used at these dosages.
Authors: Sarah B Murthi; Robert M Wise; William B Weglicki; Andrei M Komarov; Jay H Kramer Journal: Mol Cell Biochem Date: 2003-03 Impact factor: 3.396
Authors: Emily K Tarleton; Benjamin Littenberg; Charles D MacLean; Amanda G Kennedy; Christopher Daley Journal: PLoS One Date: 2017-06-27 Impact factor: 3.240