BACKGROUND: Global and regional changes in cerebral energy utilization are reported to characterize late life depression. METHODS: Twenty seven subjects with late life depression (9 prior to starting medication, 18 after starting) and 27 matched controls were evaluated with cordance, a quantitative EEG measure that reflects cerebral energy utilization. RESULTS: Global and focal (anterior and centrotemporal) differences were present in theta-band cordance between unmedicated depressed and control subjects. Depressed subjects receiving treatment had cordance patterns similar to controls. CONCLUSIONS: The presence of both diffuse and focal disturbances in energy utilization prior to initiating treatment indicates that cordance detects altered cerebral physiology in depressed patients, and that this measure may also be sensitive to treatment interventions.
BACKGROUND: Global and regional changes in cerebral energy utilization are reported to characterize late life depression. METHODS: Twenty seven subjects with late life depression (9 prior to starting medication, 18 after starting) and 27 matched controls were evaluated with cordance, a quantitative EEG measure that reflects cerebral energy utilization. RESULTS: Global and focal (anterior and centrotemporal) differences were present in theta-band cordance between unmedicated depressed and control subjects. Depressed subjects receiving treatment had cordance patterns similar to controls. CONCLUSIONS: The presence of both diffuse and focal disturbances in energy utilization prior to initiating treatment indicates that cordance detects altered cerebral physiology in depressedpatients, and that this measure may also be sensitive to treatment interventions.
Authors: Agnes S Chan; Sophia L Sze; Mei-Chun Cheung; Yvonne M Y Han; Winnie W M Leung; Dejian Shi Journal: Evid Based Complement Alternat Med Date: 2011-03-28 Impact factor: 2.629
Authors: Agnes S Chan; Mei-Chun Cheung; Sophia L Sze; Winnie W Leung; Dejian Shi Journal: Evid Based Complement Alternat Med Date: 2011-04-14 Impact factor: 2.629