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Literature DB >> 9608658

Does the latency associated transcript (LAT) of herpes simplex virus (HSV) function as a ribozyme during viral reactivation?

Abstract

The latency associated transcript (LAT) of herpes simplex virus (HSV) appears to exist as an RNA molecule only. This phenomenon is consistent with the concept of functioning at an RNA level, and several lines of evidence suggest that the LAT may be a ribozyme. This provides an insight into understanding the role of LAT during HSV reactivation.

Entities: Disease

Mesh：

Substances：
RNA, Catalytic
RNA, Viral

Year: 1998 PMID： 9608658 DOI： 10.1023/a:1007937521771

Source DB: PubMed Journal: Virus Genes ISSN： 0920-8569 Impact factor: 2.332

11 in total

Review 1. The latency-associated transcripts of herpes simplex virus: RNA in search of function.

Authors: N W Fraser; T M Block; J G Spivack
Journal: Virology Date: 1992-11 Impact factor: 3.616

Review 2. The hammerhead RNA domain, a model ribozyme.

Authors: J Bratty; P Chartrand; G Ferbeyre; R Cedergren
Journal: Biochim Biophys Acta Date: 1993-12-14

3. A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.

Authors: D C Bloom; J M Hill; G Devi-Rao; E K Wagner; L T Feldman; J G Stevens
Journal: J Virol Date: 1996-04 Impact factor: 5.103

4. Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.

Authors: E Rødahl; L Haarr
Journal: J Virol Date: 1997-02 Impact factor: 5.103

Review 5. Human herpesviruses: a consideration of the latent state.

Authors: J G Stevens
Journal: Microbiol Rev Date: 1989-09

6. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state.

Authors: R T Javier; J G Stevens; V B Dissette; E K Wagner
Journal: Virology Date: 1988-09 Impact factor: 3.616

1. A speculated ribozyme site in the herpes simplex virus type 1 latency-associated transcript gene is not essential for a wild-type reactivation phenotype.

Authors: Dale Carpenter; Sukhpreet Singh; Nelson Osorio; Chinhui Hsiang; Xianzhi Jiang; Ling Jin; Clinton Jones; Steven L Wechsler
Journal: J Neurovirol Date: 2008-11 Impact factor: 2.643

1 in total

Does the latency associated transcript (LAT) of herpes simplex virus (HSV) function as a ribozyme during viral reactivation?

Review 1. The latency-associated transcripts of herpes simplex virus: RNA in search of function.

Review 2. The hammerhead RNA domain, a model ribozyme.

3. A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.

4. Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure.

Review 5. Human herpesviruses: a consideration of the latent state.

6. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state.

Review 7. Herpes simplex virus latency in the nervous system--a new model.

Review 8. Latency comes of age for herpesviruses.

9. Herpes simplex virus latent phase transcription facilitates in vivo reactivation.

10. Novel RNA substrates for the ribozyme from Bacillus subtilis ribonuclease P identified by in vitro selection.

1. A speculated ribozyme site in the herpes simplex virus type 1 latency-associated transcript gene is not essential for a wild-type reactivation phenotype.