Literature DB >> 9606199

Conserved boxes C and D are essential nucleolar localization elements of U14 and U8 snoRNAs.

T S Lange1, A Borovjagin, E S Maxwell, S A Gerbi.   

Abstract

Sequences necessary for nucleolar targeting were identified in Box C/D small nucleolar RNAs (snoRNAs) by fluorescence microscopy. Nucleolar preparations were examined after injecting fluorescein-labelled wild-type and mutated U14 or U8 snoRNA into Xenopus oocyte nuclei. Regions in U14 snoRNA that are complementary to 18S rRNA and necessary for rRNA processing and methylation are not required for nucleolar localization. Truncated U14 molecules containing Boxes C and D with or without the terminal stem localized efficiently. Nucleolar localization was abolished upon mutating just one or two nucleotides within Boxes C and D. Moreover, the spatial position of Boxes C or D in the molecule is essential. Mutations in Box C/D of U8 snoRNA also impaired nucleolar localization, suggesting the general importance of Boxes C and D as nucleolar localization sequences for Box C/D snoRNAs. U14 snoRNA is shown to be required for 18S rRNA production in vertebrates.

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Year:  1998        PMID： 9606199      PMCID： PMC1170656          DOI： 10.1093/emboj/17.11.3176

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  71 in total

1.  Accumulation of U14 small nuclear RNA in Saccharomyces cerevisiae requires box C, box D, and a 5', 3' terminal stem.

Authors:  G M Huang; A Jarmolowski; J C Struck; M J Fournier
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

2.  Identification of specific nucleotide sequences and structural elements required for intronic U14 snoRNA processing.

Authors:  L Xia; N J Watkins; E S Maxwell
Journal:  RNA       Date:  1997-01       Impact factor: 4.942

3.  The sequence of the 5' end of the U8 small nucleolar RNA is critical for 5.8S and 28S rRNA maturation.

Authors:  B A Peculis
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

4.  Depletion of U14 small nuclear RNA (snR128) disrupts production of 18S rRNA in Saccharomyces cerevisiae.

Authors:  H D Li; J Zagorski; M J Fournier
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

5.  A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.

Authors:  K T Tycowski; C M Smith; M D Shu; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

6.  U14 base-pairs with 18S rRNA: a novel snoRNA interaction required for rRNA processing.

Authors:  W Q Liang; M J Fournier
Journal:  Genes Dev       Date:  1995-10-01       Impact factor: 11.361

7.  Retention and 5' cap trimethylation of U3 snRNA in the nucleus.

Authors:  M P Terns; J E Dahlberg
Journal:  Science       Date:  1994-05-13       Impact factor: 47.728

8.  Sequence and structural elements critical for U8 snRNP function in Xenopus oocytes are evolutionarily conserved.

Authors:  B A Peculis; J A Steitz
Journal:  Genes Dev       Date:  1994-09-15       Impact factor: 11.361

Review 9.  Processing of pre-ribosomal RNA in Saccharomyces cerevisiae.

Authors:  J Venema; D Tollervey
Journal:  Yeast       Date:  1995-12       Impact factor: 3.239

Review 10.  The nucleolar snRNAs: catching up with the spliceosomal snRNAs.

Authors:  M J Fournier; E S Maxwell
Journal:  Trends Biochem Sci       Date:  1993-04       Impact factor: 13.807
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  45 in total

1.  The Rev protein is able to transport to the cytoplasm small nucleolar RNAs containing a Rev binding element.

Authors:  S B Buonomo; A Michienzi; F G De Angelis; I Bozzoni
Journal:  RNA       Date:  1999-08       Impact factor: 4.942

2.  Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes.

Authors:  J G Gall; M Bellini; Z Wu; C Murphy
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

3.  Box H and box ACA are nucleolar localization elements of U17 small nucleolar RNA.

Authors:  T S Lange; M Ezrokhi; F Amaldi; S A Gerbi
Journal:  Mol Biol Cell       Date:  1999-11       Impact factor: 4.138

4.  Nuclear retention elements of U3 small nucleolar RNA.

Authors:  W Speckmann; A Narayanan; R Terns; M P Terns
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

5.  A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA.

Authors:  B E Jády; T Kiss
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

6.  Role of the box C/D motif in localization of small nucleolar RNAs to coiled bodies and nucleoli.

Authors:  A Narayanan; W Speckmann; R Terns; M P Terns
Journal:  Mol Biol Cell       Date:  1999-07       Impact factor: 4.138

7.  p62, a novel Xenopus laevis component of box C/D snoRNPs.

Authors:  D Filippini; I Bozzoni; E Caffarelli
Journal:  RNA       Date:  2000-03       Impact factor: 4.942

8.  Multiple conserved segments of E1 small nucleolar RNA are involved in the formation of a ribonucleoprotein particle in frog oocytes.

Authors:  D D Ruhl; M E Pusateri; G L Eliceiri
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

Review 9.  Fluorescent RNA cytochemistry: tracking gene transcripts in living cells.

Authors:  T Pederson
Journal:  Nucleic Acids Res       Date:  2001-03-01       Impact factor: 16.971

10.  Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability.

Authors:  D L Lafontaine; D Tollervey
Journal:  RNA       Date:  1999-03       Impact factor: 4.942
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