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Literature DB >> 9606003

Increased prevalence of immunoglobulin A deficiency in patients with the chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).

C A Smith¹, D A Driscoll, B S Emanuel, D M McDonald-McGinn, E H Zackai, K E Sullivan.

Abstract

We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (n = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (P < 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.

Entities: Disease Gene Species

Mesh：

Substances：
Immunoglobulin A

Year: 1998 PMID： 9606003 PMCID： PMC104536 DOI： 10.1128/CDLI.5.3.415-417.1998

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

18 in total

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17 in total

1. RNAs in the sera of Persian Gulf War veterans have segments homologous to chromosome 22q11.2.

Authors: H B Urnovitz; J J Tuite; J M Higashida; W H Murphy
Journal: Clin Diagn Lab Immunol Date: 1999-05

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Journal: Cardiol Young Date: 2015-09-08 Impact factor: 1.093

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Journal: Clin Immunol Date: 2010-05-15 Impact factor: 3.969

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Journal: Cell Mol Life Sci Date: 2011-10-09 Impact factor: 9.261

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Journal: Clin Diagn Lab Immunol Date: 1999-11

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Authors: Donna M McDonald-McGinn; Kathleen E Sullivan; Bruno Marino; Nicole Philip; Ann Swillen; Jacob A S Vorstman; Elaine H Zackai; Beverly S Emanuel; Joris R Vermeesch; Bernice E Morrow; Peter J Scambler; Anne S Bassett
Journal: Nat Rev Dis Primers Date: 2015-11-19 Impact factor: 52.329