Literature DB >> 9605850

The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.

M R Koehler1, B Wissinger, V Gorboulev, H Koepsell, M Schmid.   

Abstract

Polyspecific transporters for organic cations (OCT) belong to a new protein family which also include organic anion transporters. The first human transporters from this family (OCT1, OCT2) have been recently cloned. They translocate small cations like tetraethylammonium, choline and monoamine neurotransmitters and are involved in hepatic and renal cation excretion, respectively. We have localized the OCT1 and OCT2 genes (SLC22A1, SLC22A2) on chromosome 6q26.

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Year:  1997        PMID： 9605850     DOI： 10.1159/000134720

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  11 in total

1.  Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells.

Authors:  Erik Rytting; Jordan Bryan; Marylee Southard; Kenneth L Audus
Journal:  Biochem Pharmacol       Date:  2006-12-01       Impact factor: 5.858

2.  Organic Cation Transporter 2 (OCT2/SLC22A2) Gene Variation in the South African Bantu-Speaking Population and Functional Promoter Variants.

Authors:  Nina C Wilson; Ananyo Choudhury; Nadia Carstens; Demetra Mavri-Damelin
Journal:  OMICS       Date:  2017-02-16

3.  Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.

Authors:  Rossano Cesari; Eric S Martin; George A Calin; Francesca Pentimalli; Roberta Bichi; Holly McAdams; Francesco Trapasso; Alessandra Drusco; Masayoshi Shimizu; Valeria Masciullo; Giuseppina D'Andrilli; Giovanni Scambia; Maria Cristina Picchio; Hansjuerg Alder; Andrew K Godwin; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-28       Impact factor: 11.205

Review 4.  Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets.

Authors:  Marçal Pastor-Anglada; Sandra Pérez-Torras
Journal:  Front Pharmacol       Date:  2015-02-10       Impact factor: 5.810

Review 5.  Metformin and the gastrointestinal tract.

Authors:  Laura J McCreight; Clifford J Bailey; Ewan R Pearson
Journal:  Diabetologia       Date:  2016-01-16       Impact factor: 10.122

Review 6.  Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review.

Authors:  Edith Pascale Mofo Mato; Magellan Guewo-Fokeng; M Faadiel Essop; Peter Mark Oroma Owira
Journal:  Medicine (Baltimore)       Date:  2018-07       Impact factor: 1.889

Review 7.  Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications.

Authors:  Hermann Koepsell; Katrin Lips; Christopher Volk
Journal:  Pharm Res       Date:  2007-05-01       Impact factor: 4.580

Review 8.  Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.

Authors:  Elisa Lozano; Elisa Herraez; Oscar Briz; Virginia S Robledo; Jorge Hernandez-Iglesias; Ana Gonzalez-Hernandez; Jose J G Marin
Journal:  Biomed Res Int       Date:  2013-07-31       Impact factor: 3.411

Review 9.  Membrane transporters as mediators of Cisplatin effects and side effects.

Authors:  Giuliano Ciarimboli
Journal:  Scientifica (Cairo)       Date:  2012-11-25

10.  Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa.

Authors:  Clifford Jacobs; Brendon Pearce; Mornè Du Plessis; Nisreen Hoosain; Mongi Benjeddou
Journal:  Genet Mol Biol       Date:  2014-06       Impact factor: 1.771
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