Literature DB >> 9604715

Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide.

H Kröger1, A Hauschild, M Ohde, W Thefeld, D Krüger, K Bache, W Ehrlich.   

Abstract

Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/kg i.p. nicotinamide inhibits the development of collagen II induced arthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic index and whole blood chemiluminescence. The effect is much more pronounced than with either methotrexate or nicotinamide alone at the same concentrations. Determination of GOT and GPT levels in the blood revealed that the treatment causes no toxic side effects on the liver.

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Year:  1998        PMID： 9604715     DOI： 10.1023/a:1022348132132

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  17 in total

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Authors:  R GUBNER; S AUGUST; V GINSBERG
Journal:  Am J Med Sci       Date:  1951-02       Impact factor: 2.378

Review 2.  Second-line drug therapy for rheumatoid arthritis.

Authors:  J M Cash; J H Klippel
Journal:  N Engl J Med       Date:  1994-05-12       Impact factor: 91.245

Review 3.  Long-term methotrexate therapy for rheumatoid arthritis.

Authors:  C J Scully; C J Anderson; G W Cannon
Journal:  Semin Arthritis Rheum       Date:  1991-04       Impact factor: 5.532

4.  The influence of antagonists of poly(ADP-ribose) metabolism on acetaminophen hepatotoxicity.

Authors:  H Kröger; W Ehrlich; M Klewer; R Grätz; A Dietrich; R Miesel
Journal:  Gen Pharmacol       Date:  1996-01

5.  The therapeutic effect of a combination of cofpropamine, a caffeine derivative, and cyclophosphamide on the development of adjuvant arthritis of rats and collagen arthritis of mice.

Authors:  H Kröger; J Klosa; R Grätz; A Dietrich; W Ehrlich; A Wild
Journal:  Gen Pharmacol       Date:  1996-10

6.  Synergistic effects of thalidomide and poly (ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice.

Authors:  H Kröger; R Miesel; A Dietrich; M Ohde; E Rajnavölgyi; H Ockenfels
Journal:  Inflammation       Date:  1996-04       Impact factor: 4.092

7.  Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology.

Authors:  J M Kremer; G S Alarcón; R W Lightfoot; R F Willkens; D E Furst; H J Williams; P B Dent; M E Weinblatt
Journal:  Arthritis Rheum       Date:  1994-03

8.  The use of methotrexate in steroid-resistant systemic lupus erythematosus.

Authors:  R J Rothenberg; F M Graziano; J T Grandone; J W Goldberg; D F Bjarnason; A G Finesilver
Journal:  Arthritis Rheum       Date:  1988-05

9.  Longterm drug therapy for rheumatoid arthritis in seven rheumatology private practices: II. Second line drugs and prednisone.

Authors:  T Pincus; S B Marcum; L F Callahan
Journal:  J Rheumatol       Date:  1992-12       Impact factor: 4.666

10.  Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase.

Authors:  R Miesel; M Kurpisz; H Kröger
Journal:  Inflammation       Date:  1995-06       Impact factor: 4.092
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  1 in total

1.  Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro.

Authors:  R S Funk; R Singh; L Pramann; N Gigliotti; S Islam; D P Heruth; S Q Ye; M A Chan; J S Leeder; M L Becker
Journal:  Clin Transl Sci       Date:  2016-05-11       Impact factor: 4.689
  1 in total

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