Literature DB >> 9603849

Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans.

G H Feng1, T J Leonard.   

Abstract

High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis in Aspergillus nidulans; ammonium did not. Homologous genes for aflatoxin biosynthesis in A. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. The aflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.

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Year:  1998        PMID： 9603849      PMCID： PMC106313     

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  13 in total

1.  Molecular cloning of genes related to aflatoxin biosynthesis by differential screening.

Authors:  G H Feng; F S Chu; T J Leonard
Journal:  Appl Environ Microbiol       Date:  1992-02       Impact factor: 4.792

2.  Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis.

Authors:  P K Chang; K C Ehrlich; J Yu; D Bhatnagar; T E Cleveland
Journal:  Appl Environ Microbiol       Date:  1995-06       Impact factor: 4.792

3.  Nitrate induces enzymes of the mannitol cycle and suppresses versicolorin synthesis in Aspergillus parasiticus.

Authors:  W G Niehaus; W P Jiang
Journal:  Mycopathologia       Date:  1989-09       Impact factor: 2.574

4.  The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases.

Authors:  J Beck; S Ripka; A Siegner; E Schiltz; E Schweizer
Journal:  Eur J Biochem       Date:  1990-09-11

5.  Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus.

Authors:  J H Yu; R A Butchko; M Fernandes; N P Keller; T J Leonard; T H Adams
Journal:  Curr Genet       Date:  1996-05       Impact factor: 3.886

6.  Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.

Authors:  J H Yu; T J Leonard
Journal:  J Bacteriol       Date:  1995-08       Impact factor: 3.490

7.  Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.

Authors:  C D Skory; P K Chang; J Cary; J E Linz
Journal:  Appl Environ Microbiol       Date:  1992-11       Impact factor: 4.792

8.  Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.

Authors:  F Trail; P K Chang; J Cary; J E Linz
Journal:  Appl Environ Microbiol       Date:  1994-11       Impact factor: 4.792

9.  Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis.

Authors:  C P Woloshuk; K R Foutz; J F Brewer; D Bhatnagar; T E Cleveland; G A Payne
Journal:  Appl Environ Microbiol       Date:  1994-07       Impact factor: 4.792

10.  The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis.

Authors:  P K Chang; J W Cary; J Yu; D Bhatnagar; T E Cleveland
Journal:  Mol Gen Genet       Date:  1995-08-21
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  34 in total

1.  The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development.

Authors:  Naoki Kato; Wilhelmina Brooks; Ana M Calvo
Journal:  Eukaryot Cell       Date:  2003-12

Review 2.  Relationship between secondary metabolism and fungal development.

Authors:  Ana M Calvo; Richard A Wilson; Jin Woo Bok; Nancy P Keller
Journal:  Microbiol Mol Biol Rev       Date:  2002-09       Impact factor: 11.056

Review 3.  Clustered pathway genes in aflatoxin biosynthesis.

Authors:  Jiujiang Yu; Perng-Kuang Chang; Kenneth C Ehrlich; Jeffrey W Cary; Deepak Bhatnagar; Thomas E Cleveland; Gary A Payne; John E Linz; Charles P Woloshuk; Joan W Bennett
Journal:  Appl Environ Microbiol       Date:  2004-03       Impact factor: 4.792

Review 4.  Biosynthesis of dothistromin.

Authors:  Rosie E Bradshaw; Shuguang Zhang
Journal:  Mycopathologia       Date:  2006-09       Impact factor: 2.574

5.  Monitoring of Ochratoxin A biosynthesis related genes in Penicillium verrucosum by differential display reverse transcription PCR (DDRT-PCR) experiments.

Authors:  P Färber; R Geisen
Journal:  Mycotoxin Res       Date:  2002-06       Impact factor: 3.833

6.  Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters.

Authors:  D Ryan Georgianna; Natalie D Fedorova; James L Burroughs; Andrea L Dolezal; Jin Woo Bok; Sigal Horowitz-Brown; Charles P Woloshuk; Jiujiang Yu; Nancy P Keller; Gary A Payne
Journal:  Mol Plant Pathol       Date:  2010-03       Impact factor: 5.663

7.  Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.

Authors:  M Motomura; N Chihaya; T Shinozawa; T Hamasaki; K Yabe
Journal:  Appl Environ Microbiol       Date:  1999-11       Impact factor: 4.792

8.  The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus.

Authors:  Carrie A Smith; Dominique Robertson; Bethan Yates; Dahlia M Nielsen; Doug Brown; Ralph A Dean; Gary A Payne
Journal:  Curr Genet       Date:  2008-09-24       Impact factor: 3.886

9.  Use of response surface methodology to study the effect of media composition on aflatoxin production by Aspergillus flavus.

Authors:  Mahboob Ahmad; Malik M Ahmad; Rifat Hamid; M Z Abdin; Saleem Javed
Journal:  Mycotoxin Res       Date:  2012-11-08       Impact factor: 3.833

10.  Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

Authors:  Gitanjali Yadav; Rajesh S Gokhale; Debasisa Mohanty
Journal:  PLoS Comput Biol       Date:  2009-04-10       Impact factor: 4.475
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