| Literature DB >> 9602153 |
Abstract
The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals. Copyright 1998 Elsevier Science B.V.Entities:
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Year: 1998 PMID： 9602153 DOI： 10.1016/s0169-328x(98)00051-5
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X