Literature DB >> 9600711

Enhanced secretion of substance P by cytokine-stimulated rat brain endothelium cultures.

C Cioni1, D Renzi, A Calabrò, P Annunziata.   

Abstract

Substance P (SP) was analyzed in rat brain endothelium cultures after cytokine stimulation. SP secretion was found after stimulation with high doses of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). High doses of interferon-gamma (INF-gamma) had no effect on this secretion. Elevated SP release was found to be associated with mRNA expression of beta-preprotachykinin (beta-PPT), precursor of SP, in the cells. Under cytokine stimulation, part of SP was bound to brain endothelial cell surface, suggesting the existence of an autocrine network for this neuropeptide. These findings suggest that SP may have an immunomodulatory action at the blood-brain barrier during inflammatory and autoimmune processes in the central nervous system.

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Year:  1998        PMID： 9600711     DOI： 10.1016/s0165-5728(97)00235-x

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  7 in total

1.  Substance P antagonist (CP-96,345) inhibits HIV-1 replication in human mononuclear phagocytes.

Authors:  J P Lai; W Z Ho; G X Zhan; Y Yi; R G Collman; S D Douglas
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

2.  Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.

Authors:  R Stumm; C Culmsee; M K Schafer; J Krieglstein; E Weihe
Journal:  J Neurosci       Date:  2001-02-01       Impact factor: 6.167

3.  Walker 256 tumour cells increase substance P immunoreactivity locally and modify the properties of the blood-brain barrier during extravasation and brain invasion.

Authors:  Kate M Lewis; Elizabeth Harford-Wright; Robert Vink; Alan J Nimmo; Mounir N Ghabriel
Journal:  Clin Exp Metastasis       Date:  2012-05-19       Impact factor: 5.150

4.  Human neuronal cells (NT2-N) express functional substance P and neurokinin-1 receptor coupled to MIP-1 beta expression.

Authors:  Yuan Li; Steven D Douglas; David E Pleasure; Jianping Lai; Changjiang Guo; Peter Bannerman; Marge Williams; Wenzhe Ho
Journal:  J Neurosci Res       Date:  2003-02-15       Impact factor: 4.164

5.  Blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system.

Authors:  Kate Marie Lewis; Renée Jade Turner; Robert Vink
Journal:  Int J Inflam       Date:  2013-05-29

6.  Treatment with the NK1 antagonist emend reduces blood brain barrier dysfunction and edema formation in an experimental model of brain tumors.

Authors:  Elizabeth Harford-Wright; Kate M Lewis; Mounir N Ghabriel; Robert Vink
Journal:  PLoS One       Date:  2014-05-12       Impact factor: 3.240

7.  The role of substance p in ischaemic brain injury.

Authors:  Renée J Turner; Robert Vink
Journal:  Brain Sci       Date:  2013-01-30
  7 in total

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