Literature DB >> 9600643

Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal.

M L Adams1, T J Cicero.   

Abstract

A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.

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Year:  1998        PMID： 9600643     DOI： 10.1016/s0014-2999(98)00089-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats.

Authors:  Xiu Liu; Anthony R Caggiula; Susan K Yee; Hiroko Nobuta; Alan F Sved; Robert N Pechnick; Russell E Poland
Journal:  Neuropsychopharmacology       Date:  2006-06-21       Impact factor: 7.853

2.  Critical role of nitric oxide on nicotine-induced hyperactivation of dopaminergic nigrostriatal system: Electrophysiological and neurochemical evidence in rats.

Authors:  Vincenzo Di Matteo; Massimo Pierucci; Arcangelo Benigno; Ennio Esposito; Giuseppe Crescimanno; Giuseppe Di Giovanni
Journal:  CNS Neurosci Ther       Date:  2010-03-25       Impact factor: 5.243

3.  Bupropion attenuates nicotine abstinence syndrome in the rat.

Authors:  David H Malin; J Ronald Lake; Tanya D Smith; Habil N Khambati; Rhonda L Meyers-Paal; Ana L Montellano; Ryan E Jennings; Daniel S Erwin; Stacey E Presley; Barbara A Perales
Journal:  Psychopharmacology (Berl)       Date:  2005-09-15       Impact factor: 4.530

4.  Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.

Authors:  Andrés P Varani; Ester Aso; Lirane Machado Moutinho; Rafael Maldonado; Graciela N Balerio
Journal:  Psychopharmacology (Berl)       Date:  2014-02-20       Impact factor: 4.530

5.  Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.

Authors:  José M Trigo; Andreas Zimmer; Rafael Maldonado
Journal:  Neuropharmacology       Date:  2009-04-17       Impact factor: 5.250
  5 in total

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