Literature DB >> 9600546

The anticonvulsant zonisamide scavenges free radicals.

A Mori1, Y Noda, L Packer.   

Abstract

Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9600546     DOI： 10.1016/s0920-1211(97)00097-1

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN： 0920-1211            Impact factor:   3.045


  16 in total

1.  Akitane Mori, the artistic neurochemist.

Authors:  Jiankang Liu; Midori Hiramatsu
Journal:  Neurochem Res       Date:  2008-10-21       Impact factor: 3.996

2.  In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.

Authors:  Yuto Ueda; Taku Doi; Jun Tokumaru; Akira Nakajima; Keiko Nagatomo
Journal:  Neurochem Res       Date:  2005-09       Impact factor: 3.996

Review 3.  Role of oxidative stress in epileptic seizures.

Authors:  Eun-Joo Shin; Ji Hoon Jeong; Yoon Hee Chung; Won-Ki Kim; Kwang-Ho Ko; Jae-Hyung Bach; Jau-Shyong Hong; Yukio Yoneda; Hyoung-Chun Kim
Journal:  Neurochem Int       Date:  2011-06-13       Impact factor: 3.921

Review 4.  Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?

Authors:  Svein I Johannessen; Torbjörn Tomson
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

5.  Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.

Authors:  Mitsuo Tanabe; Akiko Sakaue; Keiko Takasu; Motoko Honda; Hideki Ono
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-10-22       Impact factor: 3.000

6.  In vivo evaluation of hippocampal anti-oxidant ability of zonisamide in rats.

Authors:  J Tokumaru; Y Ueda; H Yokoyama; A Nakajima; T Doi; Y Mitsuyama; H Ohya-Nishiguchi; H Kamada
Journal:  Neurochem Res       Date:  2000-08       Impact factor: 3.996

Review 7.  Mitochondria, oxidative stress, and temporal lobe epilepsy.

Authors:  Simon Waldbaum; Manisha Patel
Journal:  Epilepsy Res       Date:  2009-10-21       Impact factor: 3.045

8.  Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brain.

Authors:  Yasemin Topçu; Erhan Bayram; Seda Ozbal; Uluç Yiş; Kazım Tuğyan; Pakize Karaoğlu; Abdullah Kumral; Osman Yılmaz; Semra Hız Kurul
Journal:  Neurol Sci       Date:  2014-06-11       Impact factor: 3.307

9.  A novel anti-Parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice.

Authors:  Ryohei Yano; Hironori Yokoyama; Hayato Kuroiwa; Hiroyuki Kato; Tsutomu Araki
Journal:  J Mol Neurosci       Date:  2009-02-07       Impact factor: 3.444

10.  Zonisamide - a review of experience and use in partial seizures.

Authors:  Angus A Wilfong; L James Willmore
Journal:  Neuropsychiatr Dis Treat       Date:  2006-09       Impact factor: 2.570
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.