Literature DB >> 9600067

The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils.

M Hannigan1, L Zhan, Y Ai, C K Huang.   

Abstract

Transforming growth factor-beta 1 (TGF-beta 1) is the strongest chemoattractant yet described for human neutrophils. It activates neither phospholipase C nor phospholipase D. It does not induce rises in intracellular calcium, degranulation, or superoxide production. The signaling pathways utilized by TGF-beta 1 are largely unknown. This report demonstrates that TGF-beta 1 activates p38 MAP kinase. The kinase inhibitor SB203580 blocks the chemotactic responses as well as actin polymerization induced by TGF-beta 1. Potential cellular targets of the p38 MAP kinase pathway which could mediate these function are discussed.

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Year:  1998        PMID： 9600067     DOI： 10.1006/bbrc.1998.8570

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

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8.  Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension.

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9.  A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.

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10.  Epithelial Cell Gene Expression Induced by Intracellular Staphylococcus aureus.

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