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Literature DB >> 9599258

Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage.

T Masuda¹, H Matsumura, Y Oyama, Y Takeda, A Jitoe, A Kida, K Hidaka.

Abstract

A chemical synthesis of cassumunins A (1) and B (2), natural curcuminoid antioxidants, was developed. The synthesis was started from o-vanillin and after nine reaction steps resulted in 20% and 26% overall yields of 1 and 2, respectively. The synthetic cassumunins showed stronger protective activity than curcumin against oxidative cell death induced by hydrogen peroxide in a rat thymocyte system.

Entities: Chemical Species

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Year: 1998 PMID： 9599258 DOI： 10.1021/np970555g

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

7 in total

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3. Curcumin glucuronides: assessing the proliferative activity against human cell lines.

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Journal: Bioorg Med Chem Date: 2013-11-12 Impact factor: 3.641

4. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

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Journal: Bioorg Med Chem Date: 2015-02-13 Impact factor: 3.641

Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage.

1. Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.

2. Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.

3. Curcumin glucuronides: assessing the proliferative activity against human cell lines.

4. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.

5. Marine natural products as novel antioxidant prototypes.

6. Recent advances in the investigation of curcuminoids.

7. Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin.