Literature DB >> 9599014

HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.

F Bertaux1, A H Sharp, C A Ross, H Lehrach, G P Bates, E Wanker.   

Abstract

HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's disease (HD). We have isolated mouse HAP1 (hap1) and have shown that expression is not enriched in areas specifically affected in HD. We have used the yeast two hybrid system to demonstrate that htt amino acids 171-230 are necessary for the hap1-htt binding and that hapl does not interact with the transgene exon 1 protein in a transgenic model of HD.

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Year:  1998        PMID： 9599014     DOI： 10.1016/s0014-5793(98)00352-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease.

Authors:  S W Davies; M Turmaine; B A Cozens; A S Raza; A Mahal; L Mangiarini; G P Bates
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

Review 2.  Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease.

Authors:  J H Cha; A S Frey; S A Alsdorf; J A Kerner; C M Kosinski; L Mangiarini; J B Penney; S W Davies; G P Bates; A B Young
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1999-06-29       Impact factor: 6.237

3.  Modeling Huntington's disease in cells, flies, and mice.

Authors:  S Sipione; E Cattaneo
Journal:  Mol Neurobiol       Date:  2001-02       Impact factor: 5.590

4.  Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT).

Authors:  Daniela C Dieterich; A James Link; Johannes Graumann; David A Tirrell; Erin M Schuman
Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-12       Impact factor: 11.205

5.  A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.

Authors:  Kristina B Mercer; Sarah M Szlam; Erin Manning; Kim M Gernert; Walter W Walthall; Guy M Benian; Claire-Anne Gutekunst
Journal:  J Mol Neurosci       Date:  2008-07-01       Impact factor: 3.444

6.  Does Huntingtin play a role in selective macroautophagy?

Authors:  Joan S Steffan
Journal:  Cell Cycle       Date:  2010-09-01       Impact factor: 4.534

7.  pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.

Authors:  Raúl Pardo; Maria Molina-Calavita; Ghislaine Poizat; Guy Keryer; Sandrine Humbert; Frédéric Saudou
Journal:  Mol Brain       Date:  2010-06-01       Impact factor: 4.041

8.  Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells.

Authors:  Kimberly D Mackenzie; Michael D Duffield; Heshan Peiris; Lucy Phillips; Mark P Zanin; Ee Hiok Teo; Xin-Fu Zhou; Damien J Keating
Journal:  J Physiol       Date:  2013-12-23       Impact factor: 5.182

9.  Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.

Authors:  Tie-Shan Tang; Huiping Tu; Edmond Y W Chan; Anton Maximov; Zhengnan Wang; Cheryl L Wellington; Michael R Hayden; Ilya Bezprozvanny
Journal:  Neuron       Date:  2003-07-17       Impact factor: 17.173

Review 10.  Huntingtin associated protein 1 and its functions.

Authors:  Linda Lin-yan Wu; Xin-Fu Zhou
Journal:  Cell Adh Migr       Date:  2009-01-26       Impact factor: 3.405
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