E J Price1, S P Rigby, U Clancy, P J Venables. 1. Department of Rheumatology, Charing Cross Hospital and Kennedy Institute of Rheumatology, London, England, UK.
Abstract
OBJECTIVE: To establish whether there is a place for low dose azathioprine (AZA) as a disease modifying agent in patients with uncomplicated primary Sjögren's syndrome (SS). METHODS:Twenty-five patients with primary SS were entered into a double blind, placebo controlled trial of AZA (1 mg/kg/day) for a period of 6 months. RESULTS: Six patients, all receiving active drug, withdrew because of side effects. There was no significant change in disease activity variables when measured clinically, serologically, or histologically. CONCLUSION: This trial suggests that low dose AZA does not have a role as a disease modifying agent in SS.
RCT Entities:
OBJECTIVE: To establish whether there is a place for low dose azathioprine (AZA) as a disease modifying agent in patients with uncomplicated primary Sjögren's syndrome (SS). METHODS: Twenty-five patients with primary SS were entered into a double blind, placebo controlled trial of AZA (1 mg/kg/day) for a period of 6 months. RESULTS: Six patients, all receiving active drug, withdrew because of side effects. There was no significant change in disease activity variables when measured clinically, serologically, or histologically. CONCLUSION: This trial suggests that low dose AZA does not have a role as a disease modifying agent in SS.
Authors: J M van Woerkom; A A Kruize; R Geenen; E N van Roon; R Goldschmeding; S M M Verstappen; J A G van Roon; J W J Bijlsma Journal: Ann Rheum Dis Date: 2007-01-12 Impact factor: 19.103
Authors: E-K Tensing; D C Nordström; S Solovieva; K-O Schauman; I Sippo-Tujunen; T Helve; S Natah; J Ma; T F Li; Y T Konttinen Journal: Ann Rheum Dis Date: 2003-10 Impact factor: 19.103