Literature DB >> 9598687

Severe neuropathy after high dose carboplatin in three patients receiving multidrug chemotherapy.

O Heinzlef1, J P Lotz, E Roullet.   

Abstract

Three patients are described who developed a severe neuropathy after chemotherapy with high dose cis-diamine-(1,1-cyclobutane dicarboxylato) platinum (carboplatin). This toxic side effect, which is unusual at conventional doses, might become more frequent as increasing doses are administered to overcome drug resistance in cancer treatment, and might limit its use at very high doses before haematopoietic stem cell transplantation.

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Year:  1998        PMID: 9598687      PMCID: PMC2170092          DOI: 10.1136/jnnp.64.5.667

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  9 in total

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Review 5.  Molecular mechanisms of resistance and toxicity associated with platinating agents.

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Authors:  Sousana Amptoulach; Nicolas Tsavaris
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9.  Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.

Authors:  Mark R Kelley; Yanlin Jiang; Chunlu Guo; April Reed; Hongdi Meng; Michael R Vasko
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  9 in total

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