T B West1, T S Alster. 1. Washington Institute of Dermatologic Laser Surgery, DC, USA.
Abstract
BACKGROUND: Augmentation of soft tissue defects can be achieved through intradermal injection of silicone, animal collagen, plasma-gelatin mixture, and fat. Due to their rapid degradation in vivo, however, clinical effects are typically transient. The use of autologous human collagen could conceivably result in sustained clinical improvement due to decreased collagen degradation. OBJECTIVE: The purpose of this study was to determine whether prolonged dermal correction could be achieved through injection of autologous human fibroblasts. RESULTS: Significant sustained clinical improvement was observed in two of the original 12 patients entered into the study. The nasolabial fold region was shown to be the most responsive facial area to treatment. CONCLUSIONS: The use of injectable autologous human collagen for soft tissue correction remains an intriguing prospect. While the findings of this study indicate possible sustained clinical improvement using this autologous system in some patients, it remains difficult to predict the degree and duration of individual response in various areas.
BACKGROUND: Augmentation of soft tissue defects can be achieved through intradermal injection of silicone, animal collagen, plasma-gelatin mixture, and fat. Due to their rapid degradation in vivo, however, clinical effects are typically transient. The use of autologous human collagen could conceivably result in sustained clinical improvement due to decreased collagen degradation. OBJECTIVE: The purpose of this study was to determine whether prolonged dermal correction could be achieved through injection of autologous human fibroblasts. RESULTS: Significant sustained clinical improvement was observed in two of the original 12 patients entered into the study. The nasolabial fold region was shown to be the most responsive facial area to treatment. CONCLUSIONS: The use of injectable autologous human collagen for soft tissue correction remains an intriguing prospect. While the findings of this study indicate possible sustained clinical improvement using this autologous system in some patients, it remains difficult to predict the degree and duration of individual response in various areas.
Authors: Hongjun Wang; Clemens A Van Blitterswijk; Marion Bertrand-De Haas; Arnold H Schuurman; Evert N Lamme Journal: In Vitro Cell Dev Biol Anim Date: 2004 Sep-Oct Impact factor: 2.416
Authors: Mohammad Ali Nilforoushzadeh; Amir Hossein Siadat; Mojgan Arianrad; Fariba Moulavi; Elahe Haft Baradaran; Mohhamad Hossein Nasr Esfahani Journal: J Res Med Sci Date: 2010-05 Impact factor: 1.852