| Literature DB >> 9597128 |
Abstract
Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.Mesh:
Year: 1998 PMID: 9597128 DOI: 10.1146/annurev.immunol.16.1.163
Source DB: PubMed Journal: Annu Rev Immunol ISSN: 0732-0582 Impact factor: 28.527