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Literature DB >> 9596787

Regulation of distal nephron K+ channels (ROMK) mRNA expression by aldosterone in rat kidney.

Abstract

1. The expression of ROMK mRNA isoforms in rat kidney was measured using competitive polymerase chain reaction. Under basal conditions the expression of ROMK2 and 3 mRNA was significantly higher than that of ROMK1 or 6. 2. Administration of aldosterone for a period of 1 week significantly increased the mRNA expression not only of the alpha1-subunit of the Na+-K+-ATPase, but also of ROMK2, 3 and 6. 3. These data not only provide evidence that ROMK K+ channels may be involved with mineralocorticoid-sensitive K+ secretion in the distal nephron, but also demonstrate for the first time that ROMK6 may be involved in this process.

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Year: 1998 PMID： 9596787 PMCID： PMC2230996 DOI： 10.1111/j.1469-7793.1998.629bm.x

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

14 in total

1. Localization of alpha-isoforms of Na(+)-K(+)-ATPase in rat kidney by in situ hybridization.

Authors: N Farman; I Corthesy-Theulaz; J P Bonvalet; B C Rossier
Journal: Am J Physiol Date: 1991-03

2. A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop.

Authors: W H Wang; S White; J Geibel; G Giebisch
Journal: Am J Physiol Date: 1990-02

3. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

Authors: K Ho; C G Nichols; W J Lederer; J Lytton; P M Vassilev; M V Kanazirska; S C Hebert
Journal: Nature Date: 1993-03-04 Impact factor: 49.962

4. The luminal K+ channel of the thick ascending limb of Henle's loop.

Authors: M Bleich; E Schlatter; R Greger
Journal: Pflugers Arch Date: 1990-01 Impact factor: 3.657

5. Localization of the ROMK protein on apical membranes of rat kidney nephron segments.

Authors: J Z Xu; A E Hall; L N Peterson; M J Bienkowski; T E Eessalu; S C Hebert
Journal: Am J Physiol Date: 1997-11

6. ROMK inwardly rectifying ATP-sensitive K+ channel. I. Expression in rat distal nephron segments.

Authors: W S Lee; S C Hebert
Journal: Am J Physiol Date: 1995-06

7. ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms.

Authors: M A Boim; K Ho; M E Shuck; M J Bienkowski; J H Block; J L Slightom; Y Yang; B M Brenner; S C Hebert
Journal: Am J Physiol Date: 1995-06

8. Aldosterone-mediated Na/K-ATPase expression is alpha 1 isoform specific in the renal cortical collecting duct.

Authors: P A Welling; M Caplan; M Sutters; G Giebisch
Journal: J Biol Chem Date: 1993-11-05 Impact factor: 5.157

9. Adrenalectomy reduces alpha 1 and not beta 1 Na(+)-K(+)-ATPase mRNA expression in rat distal nephron.

Authors: N Farman; N Coutry; N Logvinenko; M Blot-Chabaud; R Bourbouze; J P Bonvalet
Journal: Am J Physiol Date: 1992-10

10. Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney.

Authors: M J Field; B A Stanton; G H Giebisch
Journal: J Clin Invest Date: 1984-11 Impact factor: 14.808

12 in total

10. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.

Authors: Aaron M Ring; Qiang Leng; Jesse Rinehart; Frederick H Wilson; Kristopher T Kahle; Steven C Hebert; Richard P Lifton
Journal: Proc Natl Acad Sci U S A Date: 2007-02-22 Impact factor: 11.205

Regulation of distal nephron K+ channels (ROMK) mRNA expression by aldosterone in rat kidney.

1. Localization of alpha-isoforms of Na(+)-K(+)-ATPase in rat kidney by in situ hybridization.

2. A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop.

3. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

4. The luminal K+ channel of the thick ascending limb of Henle's loop.

5. Localization of the ROMK protein on apical membranes of rat kidney nephron segments.

6. ROMK inwardly rectifying ATP-sensitive K+ channel. I. Expression in rat distal nephron segments.

7. ROMK inwardly rectifying ATP-sensitive K+ channel. II. Cloning and distribution of alternative forms.

8. Aldosterone-mediated Na/K-ATPase expression is alpha 1 isoform specific in the renal cortical collecting duct.

9. Adrenalectomy reduces alpha 1 and not beta 1 Na(+)-K(+)-ATPase mRNA expression in rat distal nephron.

10. Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney.

1. Stable, polarised, functional expression of Kir1.1b channel protein in Madin-Darby canine kidney cell line.

Review 2. Molecular diversity and regulation of renal potassium channels.

Review 3. The role of ENaC in vascular endothelium.

Review 4. The WNK kinase network regulating sodium, potassium, and blood pressure.

Review 5. Regulation of transport in the connecting tubule and cortical collecting duct.

6. Inhibition of K+ secretion in the distal nephron in nephrotic syndrome: possible role of albuminuria.

Review 7. Key developments in renin-angiotensin-aldosterone system inhibition.

Review 8. Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism.

9. The ROMK potassium channel is present in mammalian urinary tract epithelia and muscle.

10. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis.