Literature DB >> 9596784

Clearance of Shigella flexneri infection occurs through a nitric oxide-independent mechanism.

S S Way1, M B Goldberg.   

Abstract

Nitric oxide (NO) generated by gamma interferon (IFN-gamma) activation of macrophages mediates the killing of many intracellular pathogens. IFN-gamma is essential to innate resistance to Shigella flexneri infection. We demonstrate that NO is produced following S. flexneri infection both in mice and in activated cells in vitro and that while it is able to kill S. flexneri in a cell-free system, it is not required for clearance of S. flexneri in either infected mice or in activated cells in vitro.

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Year:  1998        PMID： 9596784      PMCID： PMC108306          DOI： 10.1128/IAI.66.6.3012-3016.1998

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  32 in total

Review 1.  Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

Authors:  F C Fang
Journal:  J Clin Invest       Date:  1997-06-15       Impact factor: 14.808

2.  Identification of nitric oxide synthase as a protective locus against tuberculosis.

Authors:  J D MacMicking; R J North; R LaCourse; J S Mudgett; S K Shah; C F Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

3.  Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection.

Authors:  T M Doherty; A Sher
Journal:  J Immunol       Date:  1997-05-15       Impact factor: 5.422

Review 4.  Nitric oxide and macrophage function.

Authors:  J MacMicking; Q W Xie; C Nathan
Journal:  Annu Rev Immunol       Date:  1997       Impact factor: 28.527

5.  In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis.

Authors:  D Islam; B Veress; P K Bardhan; A A Lindberg; B Christensson
Journal:  Infect Immun       Date:  1997-02       Impact factor: 3.441

6.  Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates.

Authors:  E R Rhoades; I M Orme
Journal:  Infect Immun       Date:  1997-04       Impact factor: 3.441

7.  Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis.

Authors:  C M Fernandez-Prada; D L Hoover; B D Tall; M M Venkatesan
Journal:  Infect Immun       Date:  1997-04       Impact factor: 3.441

8.  Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection.

Authors:  L L van de Verg; C P Mallett; H H Collins; T Larsen; C Hammack; T L Hale
Journal:  Infect Immun       Date:  1995-05       Impact factor: 3.441

9.  Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium.

Authors:  M A De Groote; T Testerman; Y Xu; G Stauffer; F C Fang
Journal:  Science       Date:  1996-04-19       Impact factor: 47.728

10.  Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.

Authors:  T M Scharton-Kersten; G Yap; J Magram; A Sher
Journal:  J Exp Med       Date:  1997-04-07       Impact factor: 14.307
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  4 in total

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Authors:  R Raqib; S M Mia; F Qadri; T I Alam; N H Alam; A K Chowdhury; M M Mathan; J Andersson
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

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Authors:  Vitaliy B Borisov; Elena Forte
Journal:  Int J Mol Sci       Date:  2022-06-30       Impact factor: 6.208

3.  The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response.

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Journal:  Sci Rep       Date:  2016-07-20       Impact factor: 4.379

4.  Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection.

Authors:  Valeria Ciancarella; Luigi Lembo-Fazio; Ida Paciello; Anna-Karin Bruno; Sébastien Jaillon; Sara Berardi; Marialuisa Barbagallo; Shiri Meron-Sudai; Dani Cohen; Antonio Molinaro; Giacomo Rossi; Cecilia Garlanda; Maria Lina Bernardini
Journal:  PLoS Pathog       Date:  2018-12-07       Impact factor: 6.823
  4 in total

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