Literature DB >> 959669

Intersubject variation of warfarin binding to protein in serum of normal subjects.

A Yacobi, R G Stoll, A R DiSanto, G Levy.   

Abstract

The protein binding of warfarin was determined in the serum of 18 normal adult subjects (8 males and 10 females). A statistically significant negative correlation between free fraction of warfarin and albumin concentration was found. The free fraction of warfarin in the serum of women was significantly larger than that in the serum of men, apparently due to the lower albumin concentration in the serum of women.

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Year:  1976        PMID： 959669

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  6 in total

Review 1.  Practical issues with vitamin K antagonists: elevated INRs, low time-in-therapeutic range, and warfarin failure.

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Review 2.  Protein binding of coumarin anticoagulants in disease states.

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Journal:  Clin Pharmacokinet       Date:  1977 Mar-Apr       Impact factor: 6.447

3.  Protein binding of warfarin.

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Review 4.  Drug interactions with warfarin.

Authors:  M J Serlin; A M Breckenridge
Journal:  Drugs       Date:  1983-06       Impact factor: 9.546

5.  Effect of age and sex on the plasma binding of acidic and basic drugs.

Authors:  R K Verbeeck; J A Cardinal; S M Wallace
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

6.  Effect of sertraline on protein binding of warfarin.

Authors:  G Apseloff; K D Wilner; N Gerber; L M Tremaine
Journal:  Clin Pharmacokinet       Date:  1997       Impact factor: 6.447
  6 in total

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