Literature DB >> 959468

Barbital alteration of central nervous system sensitivity to hexobarbital in the rat.

R C Schnell, R E Stoll, T D Prosser.   

Abstract

Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.

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Year:  1976        PMID： 959468     DOI： 10.1007/BF00428708

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  11 in total

1.  DISTRIBUTION AND METABOLISM OF BARBITAL-14C IN TOLERANT AND NONTOLERANT RATS.

Authors:  A G EBERT; G K YIM; T S MIYA
Journal:  Biochem Pharmacol       Date:  1964-09       Impact factor: 5.858

2.  Induction of increased meprobamate metabolism in rats pretreated with some neurotropic drugs.

Authors:  R KATO; P VASSANELLI
Journal:  Biochem Pharmacol       Date:  1962-08       Impact factor: 5.858

3.  The enzymatic metabolism of hexobarbital (evipal).

Authors:  J R COOPER; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1955-08       Impact factor: 4.030

4.  The fate of pentobarbital in man and dog and a method for its estimation in biological material.

Authors:  B B BRODIE; J J BURNS; L C MARK; P A LIEF; E BERNSTEIN; E M PAPPER
Journal:  J Pharmacol Exp Ther       Date:  1953-09       Impact factor: 4.030

5.  Differences in tolerance to hexobarbital (enhexymalum NFN) after barbital (diemalum NFN) pre-treatment during activity or rest.

Authors:  G Wahlström
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1968

6.  Hexobarbital (enhexymalum NFN) sleeping times and EEG threshold doses as measurements of tolerance to barbiturates in the rat.

Authors:  G Wahlström
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1968

7.  Hepatic drug-metabolising enzyme activity and duration of hexobarbitone anaesthesia in barbitone-dependent and withdrawn rats.

Authors:  I H Stevenson; M J Turnbull
Journal:  Biochem Pharmacol       Date:  1968-11       Impact factor: 5.858

8.  Kinetics of pharmacologic effects.

Authors:  G Levy
Journal:  Clin Pharmacol Ther       Date:  1966 May-Jun       Impact factor: 6.875

9.  Estimation of sensitivity to hexobarbitone (enhexymal NFN) in rats by an EEG threshold.

Authors:  G Wahlström
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1966

10.  Similarity in cns sensitivity to hexobarbital in the rat and mouse as determined by an analytical, a pharmacokinetic, and an electroencephalographic measure.

Authors:  R C Schnell; R E Stoll; R E Johnston; T D Prosser; R M Paolino; W F Bousquet
Journal:  Pharmacology       Date:  1975       Impact factor: 2.547
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  3 in total

1.  Potentiation of hexobarbital and amphetamine effects in male and female rats physically dependent on morphine.

Authors:  G A Lesher; G R Spratto
Journal:  Psychopharmacology (Berl)       Date:  1978-04-28       Impact factor: 4.530

2.  Experimental dependence on barbiturates. II. Relationship between drug levels in serum and brain and the development of dependence in rats.

Authors:  E Tagashira; T Izumi; S Yanaura
Journal:  Psychopharmacology (Berl)       Date:  1979-01-31       Impact factor: 4.530

3.  Barbitone-induced tolerance to the effects of sedative-hypnotics and related compounds on operant behaviour in the rat.

Authors:  J M Carney; J A Rosecrans; M R Vasko
Journal:  Br J Pharmacol       Date:  1979-02       Impact factor: 8.739
  3 in total

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