| Literature DB >> 9593963 |
D Wu1, J G Clement, W M Pardridge.
Abstract
The blood-brain barrier (BBB) permeability to [3H]-azidodeoxythymidine (AZT), deoxythiacytidine (3TC), and thymidine was studied using both an intravenous injection/external organ (IV/EO) method and an internal carotid artery perfusion (ICAP) technique in parallel with [14C]-sucrose as a plasma volume marker. The brain volumes of distribution (VD) of the three compounds approximated that of sucrose with either method. Although the lipid solubility of AZT, as determined by the 1-octanol/buffer partition coefficient (P), was 16-fold higher than that of thymidine, the BBB permeability-surface area (PS) products were almost identical, consistent with preferential efflux of AZT from brain to blood. Copyright 1998Elsevier Science B.V.Entities:
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Year: 1998 PMID： 9593963 DOI： 10.1016/s0006-8993(98)00139-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252