Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antipneumococcal activity of grepafloxacin compared to that of other agents by time-kill methodology.

Literature DB >> 9593163

Antipneumococcal activity of grepafloxacin compared to that of other agents by time-kill methodology.

G A Pankuch¹, M R Jacobs, P C Appelbaum.

Abstract

Time-kill studies compared the activities of grepafloxacin with those of ciprofloxacin, levofloxacin, sparfloxacin, amoxicillin-clavulanate, and clarithromycin against 12 pneumococcal strains. Grepafloxacin was bactericidal after 24 h against all strains at a concentration of < or = 0.5 microg/ml, while sparfloxacin, levofloxacin, and ciprofloxacin were bactericidal at concentrations of < or = 1.0, < or = 2.0, and < or = 8.0 microg/ml, respectively. Amoxicillin-clavulanate and clarithromycin were bactericidal at 2x the MIC after 24 h against 12 of 12 strains and against all 8 macrolide-susceptible strains, respectively.

Entities: Chemical

Mesh：

Substances：

Year: 1998 PMID： 9593163 PMCID： PMC105798 DOI： 10.1128/AAC.42.5.1263

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

Review 1. Treatment and diagnosis of infections caused by drug-resistant Streptococcus pneumoniae.

Authors: M R Jacobs
Journal: Clin Infect Dis Date: 1992-07 Impact factor: 9.079

Review 2. Pharmacokinetics of sparfloxacin in healthy volunteers and patients: a review.

Authors: G Montay
Journal: J Antimicrob Chemother Date: 1996-05 Impact factor: 5.790

3. Antipneumococcal activities of RP 59500 (quinupristin-dalfopristin), penicillin G, erythromycin, and sparfloxacin determined by MIC and rapid time-kill methodologies.

Authors: G A Pankuch; C Lichtenberger; M R Jacobs; P C Appelbaum
Journal: Antimicrob Agents Chemother Date: 1996-07 Impact factor: 5.191

4. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.

Authors: G V Doern; A Brueggemann; H P Holley; A M Rauch
Journal: Antimicrob Agents Chemother Date: 1996-05 Impact factor: 5.191

5. Activity of CP99,219 compared with DU-6859a, ciprofloxacin, ofloxacin, levofloxacin, lomefloxacin, tosufloxacin, sparfloxacin and grepafloxacin against penicillin-susceptible and -resistant pneumococci.

Authors: G A Pankuch; M R Jacobs; P C Appelbaum
Journal: J Antimicrob Chemother Date: 1995-01 Impact factor: 5.790

6. Open-label crossover study to determine pharmacokinetics and penetration of two dose regimens of levofloxacin into inflammatory fluid.

Authors: J Child; D Mortiboy; J M Andrews; A T Chow; R Wise
Journal: Antimicrob Agents Chemother Date: 1995-12 Impact factor: 5.191

Review 7. Antimicrobial resistance in Streptococcus pneumoniae: an overview.

Authors: P C Appelbaum
Journal: Clin Infect Dis Date: 1992-07 Impact factor: 9.079

8. Efficacy and safety of a 10-day course of 400 or 600 milligrams of grepafloxacin once daily for treatment of acute bacterial exacerbations of chronic bronchitis: comparison with a 10-day course of 500 milligrams of ciprofloxacin twice daily.

Authors: S Chodosh; S Lakshminarayan; H Swarz; S Breisch
Journal: Antimicrob Agents Chemother Date: 1998-01 Impact factor: 5.191

9. Concentrations of OPC-17116, a new fluoroquinolone antibacterial, in serum and lung compartments.

Authors: P J Cook; J M Andrews; R Wise; D Honeybourne; H Moudgil
Journal: J Antimicrob Chemother Date: 1995-02 Impact factor: 5.790

10. MIC and time-kill study of activities of DU-6859a, ciprofloxacin, levofloxacin, sparfloxacin, cefotaxime, imipenem, and vancomycin against nine penicillin-susceptible and -resistant pneumococci.

Authors: M A Visalli; M R Jacobs; P C Appelbaum
Journal: Antimicrob Agents Chemother Date: 1996-02 Impact factor: 5.191

4 in total