Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cycloserine-induced decrease of cerebroside in myelin.

Literature DB >> 9590633

Cycloserine-induced decrease of cerebroside in myelin.

Abstract

L-Cycloserine has been shown specifically to lower brain cerebroside levels in vivo, but the extent to which the decrease in whole brain cerebroside content reflects lower myelin cerebroside levels is not known since a substantial portion of cerebroside is found in nonmyelin membranes. The present report demonstrates that chronically administered cycloserine lowers the proportion of cerebroside in rat brain myelin. Cycloserine-induced decrease of myelin cerebroside should provide a useful tool in investigating the role of cerebroside in maintaining myelin stability.

Entities: Chemical Species

Mesh：

Substances：

Year: 1998 PMID： 9590633 DOI： 10.1007/s11745-998-0226-6

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

14 in total

1. Metabolism of glycerophospholipids of myelin and microsomes in rat brain. Reutilization of precursors.

Authors: S L Miller; J A Benjamins; P Morell
Journal: J Biol Chem Date: 1977-06-25 Impact factor: 5.157

2. Myelination in rat brain: method of myelin isolation.

Authors: W T Norton; S E Poduslo
Journal: J Neurochem Date: 1973-10 Impact factor: 5.372

3. Determination of long-chain base in glycosphingolipids with fluorescamine.

Authors: A Kisic; M M Rapport
Journal: J Lipid Res Date: 1974-03 Impact factor: 5.922

4. Myelination in rat brain: changes in myelin composition during brain maturation.

Authors: W T Norton; S E Poduslo
Journal: J Neurochem Date: 1973-10 Impact factor: 5.372

5. The lipid composition of rat CNS axolemma-enriched fractions.

Authors: G H De Vries; C J Zmachinski
Journal: J Neurochem Date: 1980-02 Impact factor: 5.372

6. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

Authors: T Coetzee; N Fujita; J Dupree; R Shi; A Blight; K Suzuki; K Suzuki; B Popko
Journal: Cell Date: 1996-07-26 Impact factor: 41.582

7. The relationship between nutritional adequacy and brain myelin accumulation: a comparison of varying degrees of well fed and undernourished rats.

Authors: G N Fuller; D A Johnston; R C Wiggins
Journal: Brain Res Date: 1984-01-02 Impact factor: 3.252

Cycloserine-induced decrease of cerebroside in myelin.

1. Metabolism of glycerophospholipids of myelin and microsomes in rat brain. Reutilization of precursors.

2. Myelination in rat brain: method of myelin isolation.

3. Determination of long-chain base in glycosphingolipids with fluorescamine.

4. Myelination in rat brain: changes in myelin composition during brain maturation.

5. The lipid composition of rat CNS axolemma-enriched fractions.

6. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.

7. The relationship between nutritional adequacy and brain myelin accumulation: a comparison of varying degrees of well fed and undernourished rats.

8. Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo.

9. Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine.

10. Measurement of protein using bicinchoninic acid.

1. Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).

Review 2. Experimental therapies in the murine model of globoid cell leukodystrophy.

3. Substrate Reduction Therapy for Krabbe Disease: Exploring the Repurposing of the Antibiotic D-Cycloserine.