Literature DB >> 9590283

The impact of L1 retrotransposons on the human genome.

H H Kazazian1, J V Moran.   

Abstract

The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.

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Year:  1998        PMID: 9590283     DOI: 10.1038/ng0598-19

Source DB:  PubMed          Journal:  Nat Genet        ISSN: 1061-4036            Impact factor:   38.330


  141 in total

1.  Integration of Bombyx mori R2 sequences into the 28S ribosomal RNA genes of Drosophila melanogaster.

Authors:  D G Eickbush; D D Luan; T H Eickbush
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

2.  Target DNA chromatinization modulates nicking by L1 endonuclease.

Authors:  G J Cost; A Golding; M S Schlissel; J D Boeke
Journal:  Nucleic Acids Res       Date:  2001-01-15       Impact factor: 16.971

3.  Nucleic acid chaperone activity of the ORF1 protein from the mouse LINE-1 retrotransposon.

Authors:  S L Martin; F D Bushman
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

4.  Hypothesis: for the worst and for the best, L1Hs retrotransposons actively participate in the evolution of the human centromeric alphoid sequences.

Authors:  A M Laurent; J Puechberty; G Roizès
Journal:  Chromosome Res       Date:  1999       Impact factor: 5.239

5.  Localization of mariner DNA transposons in the human genome by PRINS.

Authors:  L T Reiter; T Liehr; B Rautenstrauss; H M Robertson; J R Lupski
Journal:  Genome Res       Date:  1999-09       Impact factor: 9.043

6.  Members of the SRY family regulate the human LINE retrotransposons.

Authors:  T Tchénio; J F Casella; T Heidmann
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

7.  Nature and structure of human genes that generate retropseudogenes.

Authors:  I Gonçalves; L Duret; D Mouchiroud
Journal:  Genome Res       Date:  2000-05       Impact factor: 9.043

8.  Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis.

Authors:  J A Bailey; L Carrel; A Chakravarti; E E Eichler
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

9.  Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.

Authors:  M Speek
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

10.  Transposons but not retrotransposons are located preferentially in regions of high recombination rate in Caenorhabditis elegans.

Authors:  L Duret; G Marais; C Biémont
Journal:  Genetics       Date:  2000-12       Impact factor: 4.562

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