Interactions between Epstein-Barr virus and the cell cycle control machinery.

Epstein-Barr virus (EBV) persists in the majority of the world's human population. In the majority of cases the infection is asymptomatic, but EBV is associated with a number of human diseases, such as infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease, gastric carcinomas and other lymphomas and lymphoproliferative diseases. In this review the evidence linking EBV with these diseases is reviewed together with recent advances in understanding the interactions between EBV and the cell cycle control machinery.