Severe bone pain as an adverse effect of cyclosporin therapy for Crohn's disease.

A case of severe bone pain associated with cyclosporin therapy for Crohn's disease is reported. Severe leg pain developed in a 32-year-old man who was receiving cyclosporin for Crohn's disease that was refractory to medical management. Leg pain was related to the dose of cyclosporin, improved with calcium channel blockade, and resolved on discontinuation of cyclosporin. This syndrome has been described in the renal transplantation literature and may be related to vasoconstriction of bone vasculature.