Literature DB >> 9588809

Mosaic genes and their role in penicillin-resistant Streptococcus pneumoniae.

R Hakenbeck1.   

Abstract

Penicillin resistance in clinical isolates of Streptococcus pneumoniae is mediated by mosaic genes encoding altered penicillin binding proteins. Mosaic sequence blocks are the result of a genetic exchange between related streptococcal species. It is likely that resistance has emerged in commensal streptococci before being transferred into the pneumococcus. Closely related mosaic genes are found in different pneumococcal clones and in different streptococcal species isolated worldwide since the first reports on such strains in the late 70s, demonstrating the importance of commensal streptococci for the spread of selectable markers in naturally transforming pathogens.

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Year:  1998        PMID： 9588809     DOI： 10.1002/elps.1150190423

Source DB:  PubMed          Journal:  Electrophoresis        ISSN： 0173-0835            Impact factor:   3.535


  18 in total

1.  All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis.

Authors:  A Amoroso; D Demares; M Mollerach; G Gutkind; J Coyette
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

2.  Unique variations of pbp2b sequences in penicillin-nonsusceptible Streptococcus pneumoniae isolates from Korea.

Authors:  Jin Yang Baek; Kwan Soo Ko; Won Sup Oh; Sook-In Jung; Yeon Sook Kim; Hyun-Ha Chang; Hyuck Lee; Shin Woo Kim; Kyong Ran Peck; Nam Yong Lee; Jae-Hoon Song
Journal:  J Clin Microbiol       Date:  2004-04       Impact factor: 5.948

Review 3.  Origins and evolution of antibiotic resistance.

Authors:  Julian Davies; Dorothy Davies
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

4.  Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.

Authors:  Todd A Davies; Wenchi Shang; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

5.  In vitro activities of RWJ-54428 (MC-02,479) against multiresistant gram-positive bacteria.

Authors:  S Chamberland; J Blais; M Hoang; C Dinh; D Cotter; E Bond; C Gannon; C Park; F Malouin; M N Dudley
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

6.  Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae.

Authors:  K Kosowska-Shick; P L McGhee; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

7.  Isolation of tetracycline-resistant Megasphaera elsdenii strains with novel mosaic gene combinations of tet(O) and tet(W) from swine.

Authors:  Thaddeus B Stanton; Samuel B Humphrey
Journal:  Appl Environ Microbiol       Date:  2003-07       Impact factor: 4.792

Review 8.  Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics.

Authors:  Marilyn C Roberts
Journal:  Mol Biotechnol       Date:  2004-09       Impact factor: 2.695

9.  Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity.

Authors:  Mototsugu Yamada; Takashi Watanabe; Takako Miyara; Nobuyoshi Baba; Jun Saito; Yasuo Takeuchi; Fukuichi Ohsawa
Journal:  Antimicrob Agents Chemother       Date:  2007-08-27       Impact factor: 5.191

10.  Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.

Authors:  Yumiko Sanbongi; Takashi Ida; Midori Ishikawa; Yumi Osaki; Hiroshi Kataoka; Takahisa Suzuki; Kumiko Kondo; Fukuichi Ohsawa; Minoru Yonezawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191
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