Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets.

The effect of chronic consumption of palm oil diets on serum levels of some liver enzymes in rat was investigated. Two groups of rats were fed on either fresh or thermally oxidized palm oil, mixed at 15% level for 18 weeks and their effects on serum levels of alkaline phosphatase (EC 3.1.3.1), aspartate aminotransferase (EC 2.6.1.1) and alanine aminotransferase (EC 2.6.1.2) enzymes were compared with a control group receiving normal rat feed. The levels of alkaline phosphatase (ALP) in the two groups were significantly higher (P < 0.05-0.01) than control. Mean ALP levels were significantly different in the two test groups (P < 0.05). Similarly, there was significant elevation (P < 0.05-0.01) of aspartate aminotransferase (AST) levels in oxidized oil-fed and fresh oil-fed groups when compared with the control. The mean alanine aminotransferase (ALT) level was significantly higher (P < 0.01) in the oxidized oil-fed group than the control and fresh oil-fed groups. The results indicate that chronic consumption of thermoxidized palm oil, with its accompanying hazardous free radicals, may be more injurious to liver cell integrity than fresh palm oil.