Literature DB >> 9587945

Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese.

T Yokoi1, T Kamataki.   

Abstract

Genetic polymorphism of drug metabolizing enzymes, particularly cytochrome P450(CYP), is an important cause of adverse drug reactions. Multiple gene mutations in CYP have been shown to be phenotype. The occurrence of genetic polymorphism has been seen in genes for CYP1A1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A5. This review discusses the molecular mechanism of two genetic polymorphisms, debrisoquine/sparteine (CYP2D6) coumarin (CYP2A6) polymorphisms. In addition, elucidation of gene mutations of CYP2D6 and CYP2A6 in Japanese will be discussed.

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Year:  1998        PMID： 9587945     DOI： 10.1023/a:1011913407147

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  61 in total

1.  Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes.

Authors:  A K Daly; M Armstrong; S C Monkman; M E Idle; J R Idle
Journal:  Pharmacogenetics       Date:  1991-10

2.  Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1.

Authors:  T Aoyama; S Yamano; P S Guzelian; H V Gelboin; F J Gonzalez
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

3.  Poor metabolisers of nicotine and CYP2D6 polymorphism.

Authors:  S Cholerton; A Arpanahi; N McCracken; C Boustead; H Taber; E Johnstone; J Leathart; A K Daly; J R Idle
Journal:  Lancet       Date:  1994-01-01       Impact factor: 79.321

Review 4.  Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.

Authors:  D Hoffmann; S S Hecht
Journal:  Cancer Res       Date:  1985-03       Impact factor: 12.701

5.  Biological effects of the new platelet-activating factor receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride.

Authors:  N Imanishi; M Murakami-Uchida; H Koike; Y Natsume; S Morooka
Journal:  Arzneimittelforschung       Date:  1994-03

Review 6.  P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

Authors:  D R Nelson; L Koymans; T Kamataki; J J Stegeman; R Feyereisen; D J Waxman; M R Waterman; O Gotoh; M J Coon; R W Estabrook; I C Gunsalus; D W Nebert
Journal:  Pharmacogenetics       Date:  1996-02

7.  Defective N-oxidation of sparteine in man: a new pharmacogenetic defect.

Authors:  M Eichelbaum; N Spannbrucker; B Steincke; H J Dengler
Journal:  Eur J Clin Pharmacol       Date:  1979-09       Impact factor: 2.953

8.  Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.

Authors:  J S Miles; A W McLaren; L M Forrester; M J Glancey; M A Lang; C R Wolf
Journal:  Biochem J       Date:  1990-04-15       Impact factor: 3.857

9.  Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

Authors:  F J Gonzalez; F Vilbois; J P Hardwick; O W McBride; D W Nebert; H V Gelboin; U A Meyer
Journal:  Genomics       Date:  1988-02       Impact factor: 5.736

10.  Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype.

Authors:  R Saxena; G L Shaw; M V Relling; J N Frame; D T Moir; W E Evans; N Caporaso; B Weiffenbach
Journal:  Hum Mol Genet       Date:  1994-06       Impact factor: 6.150
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  3 in total

1.  Substance use and abuse by Asian Americans and Pacific Islanders: preliminary results from four national epidemiologic studies.

Authors:  Rumi Kato Price; Nathan K Risk; Mamie Mee Wong; Renee Storm Klingle
Journal:  Public Health Rep       Date:  2002       Impact factor: 2.792

2.  Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility.

Authors:  Ya-Ping Luo; Han-Chun Chen; Md Asaduzzaman Khan; Fang-Zhi Chen; Xin-Xing Wan; Bo Tan; Fang-Dan Ou-Yang; Dian-Zheng Zhang
Journal:  Tumour Biol       Date:  2010-09-29

Review 3.  Cytochrome p450 metabolism of betel quid-derived compounds: implications for the development of prevention strategies for oral and pharyngeal cancers.

Authors:  Che-Yi Lin; Tien-Szu Pan; Chun-Chan Ting; Shih-Shin Liang; Shu-Hung Huang; Hsiu-Yueh Liu; Edward Cheng-Chuan Ko; Chung-Wei Wu; Jen-Yang Tang; Ping-Ho Chen
Journal:  ScientificWorldJournal       Date:  2013-08-01
  3 in total

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