Literature DB >> 9587193

Antibacterial and anti-inflammatory agents that target endotoxin.

T J Wyckoff1, C R Raetz, J E Jackman.   

Abstract

Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.

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Year:  1998        PMID： 9587193     DOI： 10.1016/s0966-842x(98)01230-x

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  22 in total

1.  A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis.

Authors:  S S Basu; J D York; C R Raetz
Journal:  J Biol Chem       Date:  1999-04-16       Impact factor: 5.157

Review 2.  Lipopolysaccharide endotoxins.

Authors:  Christian R H Raetz; Chris Whitfield
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

3.  Outer membrane permeability barrier in Escherichia coli mutants that are defective in the late acyltransferases of lipid A biosynthesis.

Authors:  M Vaara; M Nurminen
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

4.  Phosphorylation of the lipid A region of meningococcal lipopolysaccharide: identification of a family of transferases that add phosphoethanolamine to lipopolysaccharide.

Authors:  Andrew D Cox; J Claire Wright; Jianjun Li; Derek W Hood; E Richard Moxon; James C Richards
Journal:  J Bacteriol       Date:  2003-06       Impact factor: 3.490

5.  Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.

Authors:  Douglas A Whittington; Kristin M Rusche; Hyunshun Shin; Carol A Fierke; David W Christianson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-20       Impact factor: 11.205

6.  Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex.

Authors:  Karin Bodewits; Christian R H Raetz; John R Govan; Dominic J Campopiano
Journal:  Antimicrob Agents Chemother       Date:  2010-06-01       Impact factor: 5.191

7.  Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.

Authors:  Heather A Gennadios; Douglas A Whittington; Xuechen Li; Carol A Fierke; David W Christianson
Journal:  Biochemistry       Date:  2006-07-04       Impact factor: 3.162

8.  Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.

Authors:  Igor Mochalkin; John D Knafels; Sandra Lightle
Journal:  Protein Sci       Date:  2008-03       Impact factor: 6.725

9.  Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding.

Authors:  Heather A Gennadios; David W Christianson
Journal:  Biochemistry       Date:  2006-11-30       Impact factor: 3.162

10.  Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy.

Authors:  Andrew S Lipton; Robert W Heck; Marcy Hernick; Carol A Fierke; Paul D Ellis
Journal:  J Am Chem Soc       Date:  2008-08-30       Impact factor: 15.419
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