Literature DB >> 9586241

Protein engineering and the development of generic biosensors.

H W Hellinga1, J S Marvin.   

Abstract

Biosensors exploit the remarkable specificity of biomolecular recognition to provide analytical tools that can measure the presence of a single molecular species in a complex mixture. A new strategy is emerging in the development of biosensor technologies: molecular-engineering techniques are being used to adapt the properties of proteins to simple, generic detector instrumentation, rather than adapting instruments to the unique requirements of a natural molecule.

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Year:  1998        PMID： 9586241     DOI： 10.1016/s0167-7799(98)01174-3

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  23 in total

1.  Conversion of a maltose receptor into a zinc biosensor by computational design.

Authors:  J S Marvin; H W Hellinga
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

2.  Optical determination of glutamine using a genetically engineered protein.

Authors:  J D Dattelbaum; J R Lakowicz
Journal:  Anal Biochem       Date:  2001-04-01       Impact factor: 3.365

3.  Engineering precision RNA molecular switches.

Authors:  G A Soukup; R R Breaker
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

4.  Construction of a fluorescent biosensor family.

Authors:  Robert M de Lorimier; J Jeff Smith; Mary A Dwyer; Loren L Looger; Kevin M Sali; Chad D Paavola; Shahir S Rizk; Shamil Sadigov; David W Conrad; Leslie Loew; Homme W Hellinga
Journal:  Protein Sci       Date:  2002-11       Impact factor: 6.725

5.  Computational design of a Zn2+ receptor that controls bacterial gene expression.

Authors:  M A Dwyer; L L Looger; H W Hellinga
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-19       Impact factor: 11.205

6.  Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates.

Authors:  Shahir S Rizk; Matthew J Cuneo; Homme W Hellinga
Journal:  Protein Sci       Date:  2006-06-02       Impact factor: 6.725

7.  Protein-based biosensors for diabetic patients.

Authors:  Viviana Scognamiglio; Maria Staiano; Mose Rossi; Sabato D'Auria
Journal:  J Fluoresc       Date:  2004-09       Impact factor: 2.217

8.  Engineering a signal transduction mechanism for protein-based biosensors.

Authors:  Jonathan E Kohn; Kevin W Plaxco
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-26       Impact factor: 11.205

9.  Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins.

Authors:  Robert M de Lorimier; Yaji Tian; Homme W Hellinga
Journal:  Protein Sci       Date:  2006-07-05       Impact factor: 6.725

10.  Selection of biocatalysts for chemical synthesis.

Authors:  Stephan van Sint Fiet; Jan B van Beilen; Bernard Witholt
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-30       Impact factor: 11.205
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