Literature DB >> 9585572

Characterization of the copper chaperone Cox17 of Saccharomyces cerevisiae.

C Srinivasan1, M C Posewitz, G N George, D R Winge.   

Abstract

Assembly of functional cytochrome oxidase in yeast requires Cox17, which has been postulated to deliver copper ions to the mitochondrion for insertion into the enzyme. This role for Cox17 is supported by the observation that it binds copper as a binuclear cuprous-thiolate cluster. X-ray absorption spectroscopy, together with UV-visible absorption and emission spectroscopy, indicates the presence of bound cuprous ions, trigonally coordinated by thiolate ligands. Analysis of the EXAFS shows three Cu-S bonds at 2.26 A, plus a short Cu-Cu distance of 2.7 A, indicating a binuclear cluster in Cox17. The cuprous-thiolate cluster in Cox17 is substantially more labile than structurally related clusters in metallothioneins.

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Year:  1998        PMID： 9585572     DOI： 10.1021/bi980418y

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  13 in total

1.  Oxidative switches in functioning of mammalian copper chaperone Cox17.

Authors:  Anastassia Voronova; Wolfram Meyer-Klaucke; Thomas Meyer; Annette Rompel; Bernt Krebs; Jekaterina Kazantseva; Rannar Sillard; Peep Palumaa
Journal:  Biochem J       Date:  2007-11-15       Impact factor: 3.857

Review 2.  Metals in the "omics" world: copper homeostasis and cytochrome c oxidase assembly in a new light.

Authors:  Ivano Bertini; Gabriele Cavallaro
Journal:  J Biol Inorg Chem       Date:  2007-11-07       Impact factor: 3.358

3.  Why multiple small subunits (Y2 and Y4) for yeast ribonucleotide reductase? Toward understanding the role of Y4.

Authors:  J Ge; D L Perlstein; H H Nguyen; G Bar; R G Griffin; J Stubbe
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

4.  Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development.

Authors:  Yoshinori Takahashi; Koichiro Kako; Shin-Ichi Kashiwabara; Akio Takehara; Yoshiko Inada; Hidenori Arai; Kazuto Nakada; Hiroko Kodama; Jun-Ichi Hayashi; Tadashi Baba; Eisuke Munekata
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

Review 5.  The many highways for intracellular trafficking of metals.

Authors:  Edward Luk; Laran T Jensen; Valeria C Culotta
Journal:  J Biol Inorg Chem       Date:  2003-09-27       Impact factor: 3.358

Review 6.  Structural and functional insights of Wilson disease copper-transporting ATPase.

Authors:  Negah Fatemi; Bibudhendra Sarkar
Journal:  J Bioenerg Biomembr       Date:  2002-10       Impact factor: 2.945

Review 7.  Copper chaperones for cytochrome c oxidase and human disease.

Authors:  Iqbal Hamza; Jonathan D Gitlin
Journal:  J Bioenerg Biomembr       Date:  2002-10       Impact factor: 2.945

8.  AtCOX17, an Arabidopsis homolog of the yeast copper chaperone COX17.

Authors:  Teresa Balandin; Carmen Castresana
Journal:  Plant Physiol       Date:  2002-08       Impact factor: 8.340

9.  Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase.

Authors:  Peep Palumaa; Liina Kangur; Anastassia Voronova; Rannar Sillard
Journal:  Biochem J       Date:  2004-08-15       Impact factor: 3.857

10.  Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span.

Authors:  Stefan W Stumpferl; Oliver Stephan; Heinz D Osiewacz
Journal:  Eukaryot Cell       Date:  2004-02
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