| Literature DB >> 9585121 |
M Yoshioka1, M Matsumoto, H Togashi, K Mori, H Saito.
Abstract
The purpose of the present study was to elucidate the distribution of 5-HT6 receptor mRNA and possible physiological functions of the 5-HT6 receptor subtype using antisense oligonucleotides (AOs) in rats. Continuous intracerebroventricular injection of AOs caused a 30% reduction in the number of [3H]-lysergic acid diethylamide binding sites. Conditioned fear stress-induced increase in 5-HT release from the prefrontal cortex was significantly inhibited by treatment with AOs. The present study suggests that 5-HT6 receptors may be functionally expressed in the brain, where one of the functions appears to be in the mediation of certain anxiety disorders.Entities:
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Year: 1998 PMID： 9585121 DOI： 10.1016/s0024-3205(98)00092-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037