Literature DB >> 958412

Model for action of local anaesthetics.

A G Lee.   

Abstract

Sodium channels in nerve membranes are postulated to be surrounded by lipid molecules in the gel (or crystalline) phase. Addition of local anasethetics triggers a change in the surrounding lipids to the fluid, liquid crystalline phase, allowing the sodium channel to close with resulting local anaesthesia. The experimental evidence for this model is discussed.

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Year:  1976        PMID： 958412     DOI： 10.1038/262545a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  43 in total

1.  Pharmacological activity and membrane interactions of antiarrhythmics: 4D-QSAR/QSPR analysis.

Authors:  C D Klein; A J Hopfinger
Journal:  Pharm Res       Date:  1998-02       Impact factor: 4.200

Review 2.  A hypothesis about the endogenous analogue of general anesthesia.

Authors:  R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

3.  The action of local anesthetics on myelin structure and nerve conduction in toad sciatic nerve.

Authors:  L Mateu; O Morán; R Padrón; M Borgo; E Vonasek; G Márquez; V Luzzati
Journal:  Biophys J       Date:  1997-06       Impact factor: 4.033

4.  NMR parameters of local anesthetics as biological markers of the cell-virus interactions.

Authors:  P E Valensin; M L Bianchi-Bandinelli; M L di Cairano; E Gaggelli; G Valensin
Journal:  Arch Virol       Date:  1985       Impact factor: 2.574

5.  Fluorescent probes for asymmetric lipid bilayers: synthesis and properties in phosphatidyl choline liposomes and erythrocyte membranes.

Authors:  J L Browning; D L Nelson
Journal:  J Membr Biol       Date:  1979-08       Impact factor: 1.843

6.  Long-chain 3-hydroxy fatty acids accumulating in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies uncouple oxidative phosphorylation in heart mitochondria.

Authors:  Anelise M Tonin; Alexandre U Amaral; Estela N B Busanello; Mateus Grings; Roger F Castilho; Moacir Wajner
Journal:  J Bioenerg Biomembr       Date:  2012-10-13       Impact factor: 2.945

7.  Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.

Authors:  Estela Natacha Brandt Busanello; Ângela Zanatta; Anelise Miotti Tonin; Carolina Maso Viegas; Carmen Regla Vargas; Guilhian Leipnitz; César Augusto João Ribeiro; Moacir Wajner
Journal:  J Bioenerg Biomembr       Date:  2012-11-15       Impact factor: 2.945

8.  The effect of temperature on the nerve-blocking action of benzyl alcohol on the squid giant axon.

Authors:  A A Harper; A G Macdonald; K T Wann
Journal:  J Physiol       Date:  1983-05       Impact factor: 5.182

9.  Intrinsic differences in the perturbing ability of alkanols in bilayer: action of phospholipase A2 on the alkanol-modified phospholipid bilayer.

Authors:  G C Upreti; S Rainier; M K Jain
Journal:  J Membr Biol       Date:  1980-07-15       Impact factor: 1.843

10.  Blockade by the local anaesthetic, tetracaine, of desensitization of Ca-induced Ca release after muscarinic stimulation in smooth muscle.

Authors:  S Hishinuma; M K Uchida
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739
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