| Literature DB >> 9583803 |
G G Doxiadis1, N Otting, S G Antunes, N G de Groot, M Harvey, I I Doxiadis, M Jonker, R E Bontrop.
Abstract
The ABO blood group system is known to act as a major transplantation barrier in primates. Different primate species share the presence of A and B antigens. The polymorphism of the macaque ABO blood group genes was analyzed by cloning and sequencing the exon 7 region. In the case of the rhesus macaque (Macaca mulatta) and cynomolgus monkey (Macaca fascicularis) we were able to identify ABO blood group gene segments which cluster into two lineages, namely: *A/*O1 and *B. In addition allelic variation was observed. The 2 amino acid replacements at positions 266 and 268, which are thought to be crucial for A or B transferase activity, could be confirmed for both macaque species. Comparison of primate sequences shows that A and B reactivity was generated independently from each other in the hominoids and Old World monkey lineages. Hence, the primate A and B blood group genes are subject to convergent evolution.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9583803 DOI： 10.1111/j.1399-0039.1998.tb02970.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815