Literature DB >> 9582495

Alternative RNA processing--its role in regulating expression of calcitonin/calcitonin gene-related peptide.

H Lou1, R F Gagel.   

Abstract

The calcitonin/calcitonin gene-related peptide (CT/CGRP) gene is one of the earliest studied examples of alternative RNA processing. The regulatory mechanisms controlling this event are poorly understood. We have identified and characterized an intron element residing in intron 4 of the human CT/CGRP gene. This intron element functions to enhance polyadenylation of an embedded alternative 3'-terminal exon within the CT/CGRP gene and is potentially involved in tissue-specific regulation of CT/CGRP RNA processing.

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Year:  1998        PMID： 9582495     DOI： 10.1677/joe.0.1560401

Source DB:  PubMed          Journal:  J Endocrinol        ISSN： 0022-0795            Impact factor:   4.286


  15 in total

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3.  Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.

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Review 8.  Calcitonin gene-related peptide: physiology and pathophysiology.

Authors:  F A Russell; R King; S-J Smillie; X Kodji; S D Brain
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